During maternal-to-embryonic transition control of embryonic development gradually
switches from maternal RNAs and proteins stored in the oocyte to gene products generated …

The scarcity of tissue-specific stem cells and the complexity of their surrounding environment
have made molecular characterization of these cells particularly challenging. Through single …

The ability to visualize and quantitatively measure dynamic biological processes in vivo and
at high spatiotemporal resolution is of fundamental importance to experimental …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

DNA methylation at the C-5 position of cytosine (5mC) is one of the best-studied epigenetic
modifications and plays important roles in diverse biological processes. Iterative oxidation of …

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Gastrulation of the mouse embryo entails progressive restriction of lineage potency and the
organization of the lineage progenitors into a body plan. Here we performed a high …

The dynamics of the chromatin regulatory landscape during human early embryogenesis
remains unknown. Using DNase I hypersensitive site (DHS) sequencing, we report that the …

We present single-cell clustering using bifurcation analysis (SCUBA), a novel computational
method for extracting lineage relationships from single-cell gene expression data and …

The ovary is perhaps the most dynamic organ in the human body, only rivaled by the uterus.
The molecular mechanisms that regulate follicular growth and regression, ensuring ovarian …