A comprehensive mapping of the druggable cavities within the SARS-CoV-2 therapeutically relevant proteins by combining pocket and docking searches as …
(1) Background: Virtual screening studies on the therapeutically relevant proteins of the
severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) require a detailed …
severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) require a detailed …
Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein
Dear Editor, The organization and regulation of membraneless compartments in cells
remain one of the fundamental questions in biology 1. How cells harness condensates for …
remain one of the fundamental questions in biology 1. How cells harness condensates for …
Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2
The nucleocapsid (N) protein of SARS-CoV-2 plays a pivotal role in encapsulating the viral
genome. Developing antiviral treatments for SARS-CoV-2 is imperative due to the …
genome. Developing antiviral treatments for SARS-CoV-2 is imperative due to the …
PABPC4 broadly inhibits coronavirus replication by degrading nucleocapsid protein through selective autophagy
Y Jiao, N Kong, H Wang, D Sun, S Dong… - Microbiology …, 2021 - Am Soc Microbiol
Emerging coronaviruses (CoVs) can cause severe diseases in humans and animals, and,
as of yet, none of the currently available broad-spectrum drugs or vaccines can effectively …
as of yet, none of the currently available broad-spectrum drugs or vaccines can effectively …
Crystal structures of the SARS‐CoV‐2 nucleocapsid protein C‐terminal domain and development of nucleocapsid‐targeting nanobodies
Z Jia, C Liu, Y Chen, H Jiang, Z Wang, J Yao… - The FEBS …, 2022 - Wiley Online Library
The ongoing outbreak of COVID‐19 caused by SARS‐CoV‐2 has resulted in a serious
public health threat globally. Nucleocapsid protein is a major structural protein of SARS …
public health threat globally. Nucleocapsid protein is a major structural protein of SARS …
[HTML][HTML] Roles of existing drug and drug targets for COVID-19 management
AG Ayele, EF Enyew, ZD Kifle - Metabolism Open, 2021 - Elsevier
In December 2019, a highly transmissible, pneumonia epidemic caused by a novel
coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), erupted in …
coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), erupted in …
[HTML][HTML] Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
I Boniardi, A Corona, J Basquin, C Basquin, J Milia… - Virus Research, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic is fading, however its
etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues …
etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues …
Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein
C Chang, S Jeyachandran, NJ Hu, CL Liu… - Molecular …, 2016 - pubs.rsc.org
Nucleocapsid protein (NP), an essential RNA-binding viral protein in human coronavirus
(CoV)-infected cells, is required for the replication and transcription of viral RNA. Recent …
(CoV)-infected cells, is required for the replication and transcription of viral RNA. Recent …
Human coronaviruses and therapeutic drug discovery
LG Song, QX Xie, HL Lao, ZY Lv - Infectious Diseases of Poverty, 2021 - Springer
Abstract Background Coronaviruses (CoVs) are distributed worldwide and have various
susceptible hosts; CoVs infecting humans are called human coronaviruses (HCoVs) …
susceptible hosts; CoVs infecting humans are called human coronaviruses (HCoVs) …
Poly (ADP-ribose) polymerase inhibition in acute lung injury. A reemerging concept
C Szabo, V Martins, L Liaudet - American journal of respiratory cell …, 2020 - atsjournals.org
PARP1, the major isoform of a family of ADP-ribosylating enzymes, has been implicated in
the regulation of various biological processes including DNA repair, gene transcription, and …
the regulation of various biological processes including DNA repair, gene transcription, and …