The role of the gut microbiome in diabetes and obesity-related kidney disease

A Zaky, SJ Glastras, MYW Wong, CA Pollock… - International journal of …, 2021 - mdpi.com
Diabetic kidney disease (DKD) is a progressive disorder, which is increasing globally in
prevalence due to the increased incidence of obesity and diabetes mellitus. Despite optimal …

Gut microbiota and hypertension: association, mechanisms and treatment

Z Yang, Q Wang, Y Liu, L Wang, Z Ge, Z Li… - Clinical and …, 2023 - Taylor & Francis
Objectives Hypertension is one of the most important risk factors for cardio-cerebral vascular
diseases, which brings a heavy economic burden to society and becomes a major public …

Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19

X Bi, W Liu, X Ding, S Liang, Y Zheng, X Zhu, S Quan… - Cell reports, 2022 - cell.com
The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed
the proteome and metabolome of urine and serum samples from patients with COVID-19 …

Dietary fiber protects against diabetic nephropathy through short-chain fatty acid–mediated activation of G protein–coupled receptors GPR43 and GPR109A

YJ Li, X Chen, TK Kwan, YW Loh, J Singer… - Journal of the …, 2020 - journals.lww.com
Background Studies have reported “dysbiotic” changes to gut microbiota, such as depletion
of gut bacteria that produce short-chain fatty acids (SCFAs) through gut fermentation of fiber …

Short-chain fatty acids in chronic kidney disease: Focus on inflammation and oxidative stress regulation

G Magliocca, P Mone, BR Di Iorio, A Heidland… - International Journal of …, 2022 - mdpi.com
Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary
complications that increase comorbidity and mortality. In patients with CKD, there is a …

Specific alterations in gut microbiota in patients with chronic kidney disease: an updated systematic review

J Zhao, X Ning, B Liu, R Dong, M Bai, S Sun - Renal failure, 2021 - Taylor & Francis
Background Emerging evidence demonstrates that gut dysbiosis is implicated in the
pathogenesis of chronic kidney disease (CKD) with underlying mechanisms involving …

Postbiotics: Metabolites and mechanisms involved in microbiota-host interactions

MCG Peluzio, JA Martinez, FI Milagro - Trends in Food Science & …, 2021 - Elsevier
Background The knowledge on the mechanisms through which the metabolites produced by
the gut microbiota (postbiotics) prevent diseases, induce therapeutic responses, and behave …

Short-chain fatty acid: An updated review on signaling, metabolism, and therapeutic effects

K Rekha, B Venkidasamy, R Samynathan… - Critical Reviews in …, 2024 - Taylor & Francis
Fatty acids are good energy sources (9 kcal per gram) that aerobic tissues can use except
for the brain (glucose is an alternative source). Apart from the energy source, fatty acids are …

Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis

SB Chadchan, P Popli, CR Ambati… - Life science …, 2021 - life-science-alliance.org
Worldwide,∼ 196 million are afflicted with endometriosis, a painful disease in which
endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories on …

The central role of the gut in intensive care

A Corriero, RM Gadaleta, F Puntillo, F Inchingolo… - Critical Care, 2022 - Springer
Critically ill patients undergo early impairment of their gut microbiota (GM) due to routine
antibiotic therapies and other environmental factors leading to intestinal dysbiosis. The GM …