Social Safety Theory hypothesizes that developing and maintaining friendly social bonds is
a fundamental organizing principle of human behavior and that threats to social safety are a …

Psychological stress during childhood and adolescence increases risk of health problems
across the lifecourse, and inflammation is implicated as an underlying mechanism. To …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Exposure to any number of stressors during the first 1000 days from conception to age 2
years is important in shaping an individual's life trajectory of health and disease. Despite the …

Early adverse experience is related to psychiatric illness that occurs decades later. The
mechanisms underlying this phenomenon have not been fully identified. There is a …

Background Potential routes whereby systemic inflammation, oxidative stress and
mitochondrial dysfunction may drive the development of endothelial dysfunction and …

Exposure to childhood adversity is a critical risk factor for the development of
psychopathology. A growing field of research examines how exposure to childhood …

A child's social relationships serve critical functions during development. The interface
between a child's social world and their immune system, particularly innate immunity, which …

Background Inflammation contributes to the pathophysiology of major depressive disorder
(MDD), and anti-inflammatory strategies might therefore have therapeutic potential. This trial …

Background The social restrictions resulting from the COVID-19 pandemic had a great
impact on the routine of children and adolescents, with important consequences such as …