Chromatin, composed of DNA wrapped around an octamer of histones, is the relevant
substrate for all genetic processes in eukaryotic nuclei. Changes in chromatin structure are …

The readout of the genetic information of eukaryotic organisms is significantly regulated by
modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide …

Epigenetic phenomena are defined by reversible heritable changes in gene expression in
the absence of changes in DNA sequence. These include, among others, DNA methylation …

In mythology, the Trickster is an archetype who typically behaves selfishly and delights in
playing tricks and breaking ordinary rules. In many myths and folktales, however, the …

Publisher Summary This chapter discusses the epigenetics of eukaryotic microbes.
Eukaryotic microbes encompass the vast majority of the eukaryotic diversity. Although some …

The basic unit of DNA compaction in eukaryotes is the nucleosome. This structure consists
of approximately 147 bp of DNA wrapped around a heterooctamer of histone particles …

Histones and chromatin modifiers are quite conserved, but there is some variation, even
among the fungi. This chapter discusses what is known about chromatin structure in the …

Quo vadis, pharmaceutical research? The current situation in the development of new drugs
is problematic because the big pharmaceutical companies are lacking new drug candidates …

Fungi have a genetically controlled sex determination system, which is governed by a small,
sex-specific region in the genome called the mating-type locus (MAT). In the …