An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment

S Drożdżal, J Rosik, K Lechowicz, F Machaj… - Drug Resistance …, 2021 - Elsevier
The COVID-19 pandemic is one of the greatest threats to human health in the 21st century
with more than 257 million cases and over 5.17 million deaths reported worldwide (as of …

Ivermectin for preventing and treating COVID‐19

M Popp, M Stegemann, MI Metzendorf… - Cochrane Database …, 2021 - cochranelibrary.com
Background Ivermectin, an antiparasitic agent used to treat parasitic infestations, inhibits the
replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of …

Mechanisms of action of fluvoxamine for COVID-19: a historical review

Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …

Effect of subcutaneous casirivimab and imdevimab antibody combination vs placebo on development of symptomatic COVID-19 in early asymptomatic SARS-CoV-2 …

MP O'Brien, E Forleo-Neto, N Sarkar, F Isa, P Hou… - Jama, 2022 - jamanetwork.com
Importance Easy-to-administer anti–SARS-CoV-2 treatments may be used to prevent
progression from asymptomatic infection to symptomatic disease and to reduce viral …

[HTML][HTML] Remdesivir for the treatment of COVID‐19

F Grundeis, K Ansems, K Dahms… - … of systematic reviews, 2023 - ncbi.nlm.nih.gov
Background Remdesivir is an antiviral medicine approved for the treatment of mild‐to‐
moderate coronavirus disease 2019 (COVID‐19). This led to widespread implementation …

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

D Ao, X He, J Liu, L Xu - Signal Transduction and Targeted Therapy, 2023 - nature.com
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted
in significant casualties and put immense strain on public health systems worldwide, leading …

The clinical efficacy and safety of anti-viral agents for non-hospitalized patients with COVID-19: a systematic review and network meta-analysis of randomized …

CC Lai, YH Wang, KH Chen, CH Chen, CY Wang - Viruses, 2022 - mdpi.com
This network meta-analysis compared the clinical efficacy and safety of anti-viral agents for
the prevention of disease progression among non-hospitalized patients with COVID-19 …

Impact of COVID-19 on the liver and on the care of patients with chronic liver disease, hepatobiliary cancer, and liver transplantation: An updated EASL position paper

T Marjot, CS Eberhardt, T Boettler, LS Belli… - Journal of …, 2022 - Elsevier
The COVID-19 pandemic has presented a serious challenge to the hepatology community,
particularly healthcare professionals and patients. While the rapid development of safe and …

[HTML][HTML] Systemic corticosteroids for the treatment of COVID‐19: Equity‐related analyses and update on evidence

C Wagner, M Griesel, A Mikolajewska… - The Cochrane …, 2022 - ncbi.nlm.nih.gov
Background Systemic corticosteroids are used to treat people with COVID‐19 because they
counter hyper‐inflammation. Existing evidence syntheses suggest a slight benefit on …

IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2

M Hale, J Netland, Y Chen, CD Thouvenel… - Journal of Experimental …, 2022 - rupress.org
Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from
convalescent donors or an engineered monoclonal antibody (mAb) product. While …