Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses
Y Ma, E Frutos-Beltrán, D Kang… - Chemical Society …, 2021 - pubs.rsc.org
During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …
drug discovery culminating with the introduction of therapies able to stop human …
[HTML][HTML] Glecaprevir/pibrentasvir for 8 weeks in treatment-naive patients with chronic HCV genotypes 1–6 and compensated cirrhosis: the EXPEDITION-8 trial
Background & Aims Eight-week glecaprevir/pibrentasvir leads to high rates of sustained
virological response at post-treatment week 12 (SVR12) across HCV genotypes (GT) 1–6 in …
virological response at post-treatment week 12 (SVR12) across HCV genotypes (GT) 1–6 in …
Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018
MC Sorbo, V Cento, VC Di Maio, AYM Howe… - Drug Resistance …, 2018 - Elsevier
Nowadays, due to the development of potent Direct-Acting Antiviral Agents (DAAs) that
specifically target NS3, NS5A and NS5B viral proteins, several new and highly efficacious …
specifically target NS3, NS5A and NS5B viral proteins, several new and highly efficacious …
Severe acute respiratory syndrome coronavirus 2 viremia is associated with coronavirus disease 2019 severity and predicts clinical outcomes
JL Jacobs, W Bain, A Naqvi, B Staines… - Clinical Infectious …, 2022 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA
(vRNA) is detected in the bloodstream of some patients with coronavirus disease 2019 …
(vRNA) is detected in the bloodstream of some patients with coronavirus disease 2019 …
[HTML][HTML] Recent advances in antiviral drug development towards dengue virus
B Troost, JM Smit - Current opinion in virology, 2020 - Elsevier
Highlights•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …
[HTML][HTML] Approved HIV reverse transcriptase inhibitors in the past decade
G Li, Y Wang, E De Clercq - Acta Pharmaceutica Sinica B, 2022 - Elsevier
HIV reverse transcriptase (RT) inhibitors are the important components of highly active
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …
antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in …
Therapy implications of hepatitis C virus genetic diversity
MA Martinez, S Franco - Viruses, 2020 - mdpi.com
Hepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An
estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection …
estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection …
Lack of effectiveness of repurposed drugs for COVID-19 treatment
MA Martinez - Frontiers in Immunology, 2021 - frontiersin.org
The magnitude of the coronavirus disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the repurposing of …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the repurposing of …
Mono-and sesquiterpenes as a starting platform for the development of antiviral drugs
OI Yarovaya, NF Salakhutdinov - Russian Chemical Reviews, 2021 - iopscience.iop.org
The revies focuses on low-molecular-weight plant metabolites (mono-and sesquiterpenes)
exhibiting antiviral activity. Data on antiviral action of both essential oils and plant extracts …
exhibiting antiviral activity. Data on antiviral action of both essential oils and plant extracts …