Immunity to influenza infection in humans

DJ Topham, ML DeDiego… - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
This review discusses the human immune responses to influenza infection with some
insights from studies using animal models, such as experimental infection of mice. Recent …

Differential recognition of computationally optimized H3 hemagglutinin influenza vaccine candidates by human antibodies

N Abbadi, K Nagashima, A Pena-Briseno… - Journal of …, 2022 - Am Soc Microbiol
Among circulating influenza viruses in humans, H3N2 viruses typically evolve faster than
other subtypes and have caused disease in millions of people since emerging in 1968 …

B. 1.1. 7 (Alpha) variant is the most antigenic compared to Wuhan strain, B. 1.351, B. 1.1. 28/triple mutant and B. 1.429 variants

M Bhattacharya, AR Sharma, B Mallick… - Frontiers in …, 2022 - frontiersin.org
The rapid spread of the SARS-CoV-2 virus and its variants has created a catastrophic impact
worldwide. Several variants have emerged, including B. 1.351 (Beta), B. 1.1. 28/triple mutant …

Structural Framework for Analysis of CD4+ T-Cell Epitope Dominance in Viral Fusion Proteins

SJ Landry, RR Mettu, JK Kolls, JH Aberle, E Norton… - Biochemistry, 2023 - ACS Publications
Antigen conformation shapes CD4+ T-cell specificity through mechanisms of antigen
processing, and the consequences for immunity may rival those from conformational effects …

Preparing for the next influenza pandemic: the development of a universal influenza vaccine

MC Crank, JR Mascola… - The Journal of infectious …, 2019 - academic.oup.com
At the centenary of the 1918 influenza pandemic that took upward of 100 million lives within
1 year [1], the world remains unprepared to prevent a similar catastrophic event from …

Does Vaccine-Induced Maternally-Derived Immunity Protect Swine Offspring against Influenza a Viruses? A Systematic Review and Meta-Analysis of Challenge Trials …

S Keay, Z Poljak, F Alberts, A O'Connor, R Friendship… - Animals, 2023 - mdpi.com
Simple Summary Vaccinated mother pigs can pass vaccine protection (immunity) onto their
offspring, but in the case of influenza, the benefit is not clear. Influenza viruses evolve rapidly …

Current paradigms in COVID-19 research: proposed treatment strategies, recent trends and future directions

AK Sharma, V Sharma, A Sharma… - Current medicinal …, 2021 - ingentaconnect.com
Background: Recent pandemic of coronavirus disease caused by a novel coronavirus SARS-
CoV-2 in humans is the third outbreak by this family of viruses leading to an acute …

Convergent evolution in breadth of two VH6-1-encoded influenza antibody clonotypes from a single donor

NC Wu, SF Andrews, JE Raab, S O'Connell… - Cell host & …, 2020 - cell.com
Understanding how broadly neutralizing antibodies (bnAbs) to influenza hemagglutinin (HA)
naturally develop in humans is critical to the design of universal influenza vaccines. Several …

Targeted alteration of antibody-based immunodominance enhances the heterosubtypic immunity of an experimental PCV2 vaccine

AGM Rakibuzzaman, O Kolyvushko, G Singh, P Nara… - Vaccines, 2020 - mdpi.com
Despite the availability of commercial vaccines which can effectively prevent clinical signs,
porcine circovirus type 2 (PCV2) continues to remain an economically important swine virus …

[HTML][HTML] Nanoparticles in the prevention, diagnosis, and treatment of the influenza virus

M Nazari, F Ebrahimzadeh, M Falaki… - Nanomedicine …, 2022 - nanomedicine-rj.com
Influenza virus have its place in the Orthomyxoviridae family, comprising four types of
viruses namely influenza A, B, C, and D. Several methods are commonly used to diagnose …