Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Methods: HBO1 expression was tested in human OS tissues and cells. Genetic strategies,
including shRNA, CRISPR/Cas9 and overexpression constructs, were applied to …

B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological disorder with a
dismal prognosis. The dysregulation of histone acetylation is of great significance in the …

Recent studies demonstrate that histones are subjected to a series of short-chain fatty acid
modifications that is known as histone acylations. However, the enzymes responsible for …

Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in
multiple biological processes. However, the regulatory mechanism and functional …

We aimed to investigate the genetic mechanisms associated with coronavirus disease of
2019 (COVID-19) outcomes in the host and to evaluate the possible associations between …

We examined the expression and the potential biological function of HBO1 in non-small cell
lung cancer (NSCLC). TCGA and Oncomine databases showed that HBO1 transcripts were …

Protein acetylation is a reversible post-translational modification, and is involved in many
biological processes in cells, such as transcriptional regulation, DNA damage repair, and …

The development and growth of a normal prostate gland, as well as its physiological
functions, are regulated by the actions of androgens through androgen receptor (AR) …