Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The escalating social and economic burden of an aging world population has placed aging
research at center stage. The hallmarks of aging comprise diverse molecular mechanisms …

Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …

Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

JCI - Biological aging processes underlying cognitive decline and neurodegenerative disease
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Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …