[HTML][HTML] Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

Insights into elastin fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome

S Seeburun, S Wu, D Hemani, L Pham, D Ju, Y Xie… - Vascular …, 2023 - Elsevier
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by
fibrillin 1 (FBN1) gene mutations that results in defects in the skeletal, ocular, and …

[HTML][HTML] Senkyunolide I ameliorates thoracic aortic aneurysm and dissection in mice via inhibiting the oxidative stress and apoptosis of endothelial cells

K Zhao, H Zhu, X He, P Du, T Liang, Y Sun… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Background Thoracic aortic aneurysm and aortic dissection (TAAD) is one of the most fatal
cardiovascular diseases. Senkyunolide I (SEI) is a component of traditional Chinese …

A dual lock-and-key probe for high-fidelity visualizing abdominal aortic aneurysm-related inflammation via a PET-TICT integrated near-infrared platform

Y Yuan, S Xiong, L Lv, W Hu, X Xiong, C Li… - Chemical Engineering …, 2023 - Elsevier
The evaluation of the inflammatory response in the abdominal aortic aneurysm (AAA) is a
great challenge. Optical imaging probes enable us to detect and reveal the physiological …

[HTML][HTML] The role of immune mechanisms in abdominal aortic aneurysm: could it be a promising therapeutic strategy?

R Dinc - Acta Cardiologica Sinica, 2023 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) is an enlargement of the aorta greater than 50% in
diameter. Although up to 80% of cases result in mortality if the aneurysm ruptures, patients …

[HTML][HTML] The Potential Involvement of Glycocalyx Disruption in Abdominal Aortic Aneurysm Pathogenesis

B Rabia, S Thanigaimani, J Golledge - Cardiovascular Pathology, 2024 - Elsevier
Background Abdominal aortic aneurysm (AAA) is a weakening and expansion of the
abdominal aorta. Currently, there is no drug treatment to limit AAA growth. The glycocalyx …

Exploring the impact of gut microbiota on abdominal aortic aneurysm risk through a bidirectional Mendelian randomization analysis

X Zhou, W Ruan, T Wang, H Liu, L Du… - Journal of Vascular …, 2024 - Elsevier
Objective The abdominal aortic aneurysm (AAA) is associated with alterations in the
composition of the gut microbiota; however, the precise causal relationship remains unclear …

Therapeutic potential of natural products and underlying targets for the treatment of aortic aneurysm

W Zhao, B Li, J Hao, R Sun, P He, H Lv, M He… - Pharmacology & …, 2024 - Elsevier
Aortic aneurysm is a vascular disease characterized by irreversible vasodilatation that can
lead to dissection and rupture of the aortic aneurysm, a life-threatening condition. Thoracic …

[HTML][HTML] Global research status analysis of the association between aortic aneurysm and inflammation: a bibliometric analysis from 1999 to 2023

Q Wang, G Chen, Z Qi, Y Zeng, L Tan… - Frontiers in …, 2023 - frontiersin.org
Background Aortic aneurysm is a chronic arterial disease that can lead to aortic rupture,
causing severe complications and life-threatening risks for patients, and it is one of the …

[HTML][HTML] Body mass index and the risk of abdominal aortic aneurysm presence and postoperative mortality: a systematic review and dose-response meta-analysis

Y Wu, H Zhang, D Jiang, F Yin, P Guo… - … Journal of Surgery, 2024 - journals.lww.com
Background: The clinical data regarding the relationships between BMI and abdominal
aortic aneurysm (AAA) are inconsistent, especially for the obese and overweight patients …