Potential of mRNA-based vaccines for the control of tick-borne pathogens in one health perspective

E González-Cueto, J De La Fuente… - Frontiers in …, 2024 - frontiersin.org
The One Health approach, which integrates the health of humans, animals, plants, and
ecosystems at various levels, is crucial for addressing interconnected health threats. This is …

Malaria vaccine development: challenges and prospects

E Etefia, P Inyang-Etoh - Medical and Pharmaceutical Journal, 2023 - pharmacoj.com
This is a review on malaria vaccine development: challenges and prospects. The
development of licensed malaria vaccines have been challenging because of the multi …

Analysis of sequence diversity in Plasmodium falciparum glutamic acid-rich protein (PfGARP), an asexual blood stage vaccine candidate

R Rojrung, N Kuamsab, C Putaporntip… - Scientific Reports, 2023 - nature.com
Glutamic acid-rich protein of Plasmodium falciparum (PfGARP) binds to erythrocyte band 3
and may enhance cytoadherence of infected erythrocytes. Naturally acquired anti-PfGARP …

Immunization with PfGBP130 generates antibodies that inhibit RBC invasion by P. falciparum parasites

Y Johnson, AR Shakri, S Pond-Tor, A Jnawali… - Frontiers in …, 2024 - frontiersin.org
Background Despite decades of effort, Plasmodium falciparum malaria remains a leading
killer of children. The absence of a highly effective vaccine and the emergence of parasites …

Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

JW Lai, MJ Maah, KW Tan, R Sarip, YAL Lim… - Malaria Journal, 2022 - Springer
Background Malaria remains one of the most virulent and deadliest parasitic disease in the
world, particularly in Africa and Southeast Asia. Widespread occurrence of artemisinin …

How to Accelerate Early Stage of Malaria Vaccine Development by Optimizing Functional Assays

K Miura - Vaccines, 2024 - mdpi.com
While two Plasmodium falciparum circumsporozoite protein-based pre-erythrocytic vaccines
(PEV), RTS, S and R21, have been approved by the WHO, no blood-stage vaccine (BSV) or …

GeneTargeter: Automated In Silico Design for Genome Editing in the Malaria Parasite, Plasmodium falciparum

P Cárdenas, LY Esherick, G Chambonnier… - The CRISPR …, 2022 - liebertpub.com
Functional characterization of the multitude of poorly described proteins in the human
malarial pathogen, Plasmodium falciparum, requires tools to enable genome-scale …

Pediatric cerebral malaria

G Guenther, D Muller, D Moyo, D Postels - Current tropical medicine …, 2021 - Springer
Abstract Purpose of Review Malaria is the most important parasitic disease of humankind.
Cerebral malaria is malaria's deadliest clinical manifestation and has a profound public …

Plasmodium falciparum Glutamic Acid-Rich Protein-Independent Polyclonal Antibodies Inhibit Malaria Parasite Growth in Human Erythrocytes

CJ Schwake, RM Krueger, T Hanada… - The Journal of …, 2024 - academic.oup.com
Plasmodium falciparum glutamic acid-rich protein (PfGARP) is a recently characterized cell
surface antigen encoded by Plasmodium falciparum, the causative agent of severe human …

Recent Advancements in Radiopharmaceuticals for Infection Imaging

E Dadachova, DEN Rangel - Intracellular Pathogens: Methods and …, 2024 - Springer
COVID-19 pandemic has heightened the interest toward diagnosis and treatment of
infectious diseases. Nuclear medicine, with its powerful scintigraphic, single photon …