Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

NN Keum, E Giovannucci - Nature reviews Gastroenterology & …, 2019 - nature.com
Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

[HTML][HTML] Adipose tissue: physiology to metabolic dysfunction

AJ Richard, U White, CM Elks, JM Stephens - Endotext [internet], 2020 - ncbi.nlm.nih.gov
Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism

CN Jayasena, RA Anderson, S Llahana… - Clinical …, 2022 - Wiley Online Library
Male hypogonadism (MH) is a common endocrine disorder. However, uncertainties and
variations in its diagnosis and management exist. There are several current guidelines on …

[HTML][HTML] Intracrine androgen biosynthesis, metabolism and action revisited

L Schiffer, W Arlt, KH Storbeck - Molecular and cellular endocrinology, 2018 - Elsevier
Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Bisphenol A (BPA) leading to obesity and cardiovascular complications: a compilation of current in vivo study

R Naomi, MD Yazid, H Bahari, YY Keong… - International journal of …, 2022 - mdpi.com
BPA is one of the most common endocrine disruptors that is widely being manufactured
daily nationwide. Although scientific evidence supports claims of negative effects of BPA on …

Integrated lipidomics and targeted metabolomics analyses reveal changes in flavor precursors in psoas major muscle of castrated lambs

J Li, C Tang, Q Zhao, Y Yang, F Li, Y Qin, X Liu, X Yue… - Food Chemistry, 2020 - Elsevier
Castration may decrease off-odors and improve meat flavor. Meat flavor is generated
through complex chemical reactions that involve hydrophilic and hydrophobic flavor …

[HTML][HTML] Male obesity-related secondary hypogonadism–pathophysiology, clinical implications and management

CJ Fernandez, EC Chacko… - European …, 2019 - ncbi.nlm.nih.gov
The single most significant risk factor for testosterone deficiency in men is obesity. The
pathophysiological mechanisms involved in male obesity-related secondary hypogonadism …

Vitamin D in osteosarcopenic obesity

L Di Filippo, R De Lorenzo, A Giustina… - Nutrients, 2022 - mdpi.com
Osteosarcopenic obesity is a unique clinical condition where low bone and muscle mass
coexist in individuals with obesity. Alterations in adipose tissue, skeletal muscle and bone …

Endogenous testosterone levels and cardiovascular risk: meta-analysis of observational studies

G Corona, G Rastrelli, G Di Pasquale… - The journal of sexual …, 2018 - academic.oup.com
Introduction The relationship between endogenous testosterone (T) levels and
cardiovascular (CV) risk in men is conflicting. Aim To verify whether endogenous T levels …

Emerging trends in colorectal cancer: Dysregulated signaling pathways

R Ahmad, JK Singh, A Wunnava… - International …, 2021 - spandidos-publications.com
Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer‑related mortality globally. The American Cancer Society …