Antibiotics in the clinical pipeline in October 2019

MS Butler, DL Paterson - The Journal of antibiotics, 2020 - nature.com
The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

Mechanisms of drug-induced tolerance in Mycobacterium tuberculosis

SN Goossens, SL Sampson… - Clinical microbiology …, 2020 - Am Soc Microbiol
Successful treatment of tuberculosis (TB) can be hampered by Mycobacterium tuberculosis
populations that are temporarily able to survive antibiotic pressure in the absence of drug …

Nanosized Drug Delivery Systems to Fight Tuberculosis

T Bourguignon, JA Godinez-Leon, R Gref - Pharmaceutics, 2023 - mdpi.com
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing
antitubercular therapies are long, complex, and have severe side effects that result in low …

Machine learning to design antimicrobial combination therapies: Promises and pitfalls

JM Cantrell, CH Chung, S Chandrasekaran - Drug Discovery Today, 2022 - Elsevier
Combination therapies can overcome antimicrobial resistance (AMR) and repurpose
existing drugs. However, the large combinatorial space to explore presents a daunting …

Targeting polyketide synthase 13 for the treatment of tuberculosis

F Xia, H Zhang, H Yang, M Zheng, W Min, C Sun… - European Journal of …, 2023 - Elsevier
Tuberculosis (TB) is one of the most threatening diseases for humans, however, the drug
treatment strategy for TB has been stagnant and inadequate, which could not meet current …

Mycobacterium abscessus DosRS two-component system controls a species-specific regulon required for adaptation to hypoxia

BS Simcox, BR Tomlinson, LN Shaw… - Frontiers in Cellular and …, 2023 - frontiersin.org
Mycobacterium abscessus (Mab), an emerging opportunistic pathogen, predominantly
infects individuals with underlying pulmonary diseases such as cystic fibrosis (CF). Current …

A Comprehensive Mini Review on the Natural Product Bacopa monnieri for the Management of Alzheimer's Disease

N Jain, O Tambekar, T Goel… - The Natural Products …, 2024 - ingentaconnect.com
Central nervous system disorders are expected to profoundly impact the global healthcare
needs of the human community in this era. Senile decay of neurons is (Alzheimers Disease) …

Chrysomycin A inhibits the topoisomerase I of Mycobacterium tuberculosis

B Muralikrishnan, LK Edison, A Dusthackeer… - The Journal of …, 2022 - nature.com
Novel anti-tuberculosis drugs are essential to manage drug-resistant tuberculosis, caused
by Mycobacterium tuberculosis. We recently reported the antimycobacterial activity of …

A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs

JM Cicchese, A Sambarey, D Kirschner… - Scientific Reports, 2021 - nature.com
Tuberculosis (TB) is the deadliest infectious disease worldwide. The design of new
treatments for TB is hindered by the large number of candidate drugs, drug combinations …

Preliminary study on citrus oils antibacterial activity measured by flow cytometry: a step-by-step development

NG Nieto-Velázquez, AA Gomez-Valdez… - Antibiotics, 2021 - mdpi.com
Essential oils of Citrus sinensis and Citrus latifolia have shown biological functions as
antiseptics, anti-inflammatories, antioxidants, antifungal and antimutagenic, so the …