Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

Spatial omics has been widely heralded as the new frontier in life sciences. This term
encompasses a wide range of techniques that promise to transform many areas of biology …

The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

Matrix-assisted laser desorption–ionization mass spectrometry imaging in transmission-
mode geometry (t-MALDI–MSI) can provide molecular information with a pixel size of 1 µm …

Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …

Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …

Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …

Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Solid tumors generate a suppressive environment that imposes an overwhelming burden on
the immune system. Nutrient depletion, waste product accumulation, hypoxia, and pH …