Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Ebselen is an organoselenium compound exhibiting hydroperoxide-and peroxynitrite-
reducing activity, acting as a glutathione peroxidase and peroxiredoxin enzyme mimetic …

Among the drug targets being investigated for SARS-CoV-2, the viral main protease (Mpro)
is one of the most extensively studied. Mpro is a cysteine protease that hydrolyzes the viral …

Selenium is a trace element essential to human health largely because of its incorporation
into selenoproteins that have a wide range of protective functions. Selenium has an ongoing …

Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …

Selenium is an essential trace element for animals and its role in the chemistry of life relies
on a unique functional group: the selenol (–SeH) group. The selenol group participates in …

Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

Selenium-containing compounds have emerged as a potentially promising treatment for
viral infections and tumor development and dissemination. Selenium per se is often …

Thioredoxin system is a ubiquitous disulfide reductase system evolutionarily conserved
through all living organisms. It contains thioredoxin (Trx), thioredoxin reductase (TrxR) and …