Towards Stem Cell Therapy for Critical-Sized Segmental Bone Defects: Current Trends and Challenges on the Path to Clinical Translation

J Quek, C Vizetto-Duarte, SH Teoh, Y Choo - Journal of Functional …, 2024 - mdpi.com
The management and reconstruction of critical-sized segmental bone defects remain a
major clinical challenge for orthopaedic clinicians and surgeons. In particular, regenerative …

A comprehensive insight into the immunomodulatory role of MSCs‐derived exosomes (MSC‐Exos) through modulating pattern‐recognition receptors (PRRs)

MY Alshahrani, SA Jasim… - Cell Biochemistry …, 2024 - Wiley Online Library
Mesenchymal stem cell‐derived exosomes (MSC‐Exos) are emerging as remarkable
agents in the field of immunomodulation with vast potential for diagnosing and treating …

The therapeutic potential of exosomes in immunotherapy

G Li, S Zhang, Y Zou, H Ai, X Zheng, K Qian… - Frontiers in …, 2024 - frontiersin.org
Exosomes are found in various tissues of the body and carry abundant contents including
nucleic acids, proteins, and metabolites, which continuously flow between cells of various …

Stem Cell-Based Acellular Therapy: Insight into Biogenesis, Bioengineering and Therapeutic Applications of Exosomes

MS Choudhery, T Arif, R Mahmood, DT Harris - Biomolecules, 2024 - mdpi.com
The vast regenerative potential of stem cells has laid the foundation for stem cell-based
therapies. However, certain challenges limit the application of cell-based therapies. The …

[PDF][PDF] Stem Cells and Exosomes-associated Therapeutic Applications

U Ahmed, M Abubakar, R Ayyoub… - Journal of Clinical and …, 2024 - researchgate.net
Exosomes are extracellular vesicles with sizes from 30 to 150 nm in diameter and modulate
the transport of multiple intracellular biological molecules including proteins, nucleic acids …