Umbilical cord-derived mesenchymal stem cell sheets transplanted subcutaneously enhance cell retention and survival more than dissociated stem cell injections

M Nakao, M Matsui, K Kim, N Nishiyama… - Stem Cell Research & …, 2023 - Springer
Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have
recently attracted attention as an alternative approach to injected cell suspensions for stem …

Clinically relevant mesenchymal stem/stromal cell sheet transplantation method for kidney disease

M Oka, S Kameishi, YK Cho, SU Song… - … Engineering Part C …, 2023 - liebertpub.com
Chronic kidney disease (CKD) is the irreversible loss of nephron function, leading to a build-
up of toxins, prolonged inflammation, and ultimately fibrosis. Currently, no effective therapies …

Rapid and effective preparation of clonal bone marrow-derived mesenchymal stem/stromal cell sheets to reduce renal fibrosis

S Kameishi, CM Dunn, M Oka, K Kim, YK Cho… - Scientific Reports, 2023 - nature.com
Abstract Allogeneic “off-the-shelf” mesenchymal stem/stromal cell (MSC) therapy requires
scalable, quality-controlled cell manufacturing and distribution systems to provide clinical …

Cause and consequence of heterogeneity in human mesenchymal stem cells: Challenges in clinical application

Z Lyu, M Xin, DR Oyston, T Xue, H Kang… - … -Research and Practice, 2024 - Elsevier
Human mesenchymal stem cells (hMSCs) are mesoderm-derived adult stem cells with self-
proliferation capacity, pluripotent differentiation potency, and excellent histocompatibility …

Mesenchymal stem cells pretreated with interferon-gamma attenuate renal fibrosis by enhancing regulatory T cell induction

S Kurawaki, A Nakashima, N Ishiuchi, R Kanai… - Scientific Reports, 2024 - nature.com
Mesenchymal stem cells (MSCs) exert their anti-inflammatory and anti-fibrotic effects by
secreting various humoral factors. Interferon-gamma (IFN-γ) can enhance these effects of …

Differential response of mesenchymal stromal cells (MSCs) to type 1 ex vivo cytokine priming: implications for MSC therapy

AJ Burnham, EM Foppiani, KL Goss, F Jang-Milligan… - Cytotherapy, 2023 - Elsevier
Background aims Mesenchymal stromal cells (MSCs) are polymorphic, adherent cells with
the capability to stimulate tissue regeneration and modulate immunity. MSCs have been …

Cellular interactions in cell sheets enhance mesenchymal stromal cell immunomodulatory properties

CM Dunn, S Kameishi, T Parker, YK Cho… - … Engineering Part A, 2023 - liebertpub.com
Immune-related applications of mesenchymal stromal cells (MSCs) in cell therapy seek to
exploit immunomodulatory paracrine signaling pathways to reduce inflammation. A key MSC …

Preclinical Evaluation of interferon-gamma primed human Wharton's jelly-derived mesenchymal stem cells

SJ Park, DS Kim, M Choi, KH Han… - Human & …, 2023 - journals.sagepub.com
The potential of human mesenchymal stem cells (MSCs) for cell therapy has been
investigated in numerous immune-mediated conditions; MSCs are considered one of the …

间充质干细胞治疗自身免疫性肝病的临床研究进展.

史婉婉, 钱建丹, 王贵强 - Journal of Clinical Hepatology …, 2023 - search.ebscohost.com
自身免疫性肝病因治疗选择和方式比较局限, 因此迫切需要寻求新的治疗方法.
间充质干细胞(MSC) 作为干细胞治疗最常见的细胞来源, 在调节先天和适应性免疫反应中发挥着 …

Clinical research advances in mesenchymal stem cells for the treatment of autoimmune liver diseases

SHI Wanwan, Q Jiandan - 临床肝胆病杂志, 2023 - lcgdbzz.org
Due to limited options and modalities for the etiological treatment of autoimmune liver
diseases, it is urgent to seek new therapeutic methods for liver autoimmune diseases. As the …