[HTML][HTML] Sexual dimorphism in innate immunity: the role of sex hormones and epigenetics

R Shepherd, AS Cheung, K Pang, R Saffery… - Frontiers in …, 2021 - frontiersin.org
Sexual dimorphism refers to differences between biological sexes that extend beyond
sexual characteristics. In humans, sexual dimorphism in the immune response has been …

The roles of androgens in humans: biology, metabolic regulation and health

M Alemany - International journal of molecular sciences, 2022 - mdpi.com
Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Sex and gender differences in health: what the COVID-19 pandemic can teach us

PA Spagnolo, JAE Manson, H Joffe - Annals of Internal Medicine, 2020 - acpjournals.org
Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach Us | Annals
of Internal Medicine Advertisement ACP Online Annals of Internal Medicine Annals of Internal …

Sex differences in differentiated thyroid cancer

L Shobab, KD Burman, L Wartofsky - Thyroid, 2022 - liebertpub.com
Background: Sex dimorphism strongly impacts tumor biology, with most cancers having a
male predominance. Uniquely, thyroid cancer (TC) is the only nonreproductive cancer with …

Why does COVID‐19 kill more elderly men than women? Is there a role for testosterone?

V Papadopoulos, L Li, M Samplaski - Andrology, 2021 - Wiley Online Library
Background Recent epidemiological data indicate that there may be a gender predisposition
to COVID‐19, with men predisposed to being most severely affected, and older men …

[HTML][HTML] Male obesity-related secondary hypogonadism–pathophysiology, clinical implications and management

CJ Fernandez, EC Chacko… - European …, 2019 - ncbi.nlm.nih.gov
The single most significant risk factor for testosterone deficiency in men is obesity. The
pathophysiological mechanisms involved in male obesity-related secondary hypogonadism …

TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease

RE Vickman, LT Aaron-Brooks, R Zhang… - Nature …, 2022 - nature.com
Autoimmune (AI) diseases can affect many organs; however, the prostate has not been
considered to be a primary target of these systemic inflammatory processes. Here, we utilize …

Repurposing the estrogen receptor modulator raloxifene to treat SARS-CoV-2 infection

M Allegretti, MC Cesta, M Zippoli, A Beccari… - Cell Death & …, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates strategies to identify …

An assessment on impact of COVID-19 infection in a gender specific manner

H Agrawal, N Das, S Nathani, S Saha, S Saini… - Stem cell reviews and …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by novel coronavirus Severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first time reported in …

[HTML][HTML] Evidence of sex differences in cellular senescence

M Ng, LN Hazrati - Neurobiology of Aging, 2022 - Elsevier
Biological sex is a factor in many conditions, including aging, neurodegenerative disease,
cancer, and more. For each of these, men and women display distinct differences in disease …