In this report we compare the effect of stimulation of peripheral mononuclear cells (PBMC)
by using two monoclonal antibodies (MoAb) directed against the CD2 receptor on T cells or …

Screening assays and methods of performing such assays are provided. In certain
examples, the assays and methods may be designed to determine whether or not two or …

It has been shown that B-cell response to an antigen is regulated by a helper T cell
responding to and specific for the same antigen molecule. This T-cell dependent B-cell …

We have deliberately targeted collaboration between T cells and certain B cells by using a
heteroconjugate (HETCONJ) antibody. This specific reagent was created by cross-linking …

In vivo conditions, the innate immune arm signals shape the activation of naive T cells,
however, it is unclear how T cells maintain their function in vitro, in experimental settings …

The effect of thymectomy on the production of antibodies was studied by immunizing mice
with hapten‐carrier conjugates. Antibody responses were analysed with monoclonal …

A. HISTORICAL PERSPECTIVE A major defining characteristic of the immune system is its
ability to" remember" prior exposure to an antigen, and to protect against subsequent …

Many different lymphokines have been reported to play a role in regulating B cell growth and
differentiation. These studies have employed model systems using non-immune or" virgin" …

The vertebrate immune system has evolved in order to allow specific attacks against
pathogens, while allowing co-existence with symbiotic microbiota and avoiding damage to …

Effector functions in the immune system are carried out by a variety of cell types, and as our
understanding of the complexity of the system expands, the number of recognized …