An update on vascular calcification and potential therapeutics

A Singh, S Tandon, C Tandon - Molecular Biology Reports, 2021 - Springer
Pathological calcification is a major cause of cardiovascular morbidities primarily in
population with chronic kidney disease (CKD), end stage renal diseases (ERSD) and …

[HTML][HTML] Role of vitamin K in chronic kidney disease: A focus on bone and cardiovascular health

F Bellone, M Cinquegrani, R Nicotera… - International Journal of …, 2022 - mdpi.com
Chronic kidney disease (CKD) is commonly associated with vitamin K deficiency. Some of
the serious complications of CKD are represented by cardiovascular disease (CVD) and …

A novel anti-osteoporosis mechanism of VK2: interfering with ferroptosis via AMPK/SIRT1 pathway in type 2 diabetic osteoporosis

C Jin, K Tan, Z Yao, B Lin, D Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Type 2 diabetic osteoporosis (T2DOP) is a chronic bone metabolic disease. Compared with
traditional menopausal osteoporosis, the long-term high glucose (HG) microenvironment …

[HTML][HTML] Vascular calcification in chronic kidney disease: an update and perspective

SC Ren, N Mao, S Yi, X Ma, JQ Zou, X Tang… - Aging and …, 2022 - ncbi.nlm.nih.gov
Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron
numbers and function and leading to end-stage renal disease and mineral disorders …

Altered vitamin K biodistribution and metabolism in experimental and human chronic kidney disease

N Kaesler, F Schreibing, T Speer… - Kidney International, 2022 - Elsevier
Chronic kidney disease (CKD) is accompanied with extensive cardiovascular calcification, in
part correlating with functional vitamin K deficiency. Here, we sought to determine causes for …

[HTML][HTML] Vitamin K supplementation for prevention of vascular calcification in chronic kidney disease patients: are we there yet?

S Roumeliotis, A Duni, V Vaios, A Kitsos… - Nutrients, 2022 - mdpi.com
Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial
calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In …

Neutrophil-to-lymphocyte ratio in relation to the risk of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a systematic review and …

WM Zhao, SM Tao, GL Liu - Renal failure, 2020 - Taylor & Francis
Aim To systematically evaluate the relationship between the neutrophil-to-lymphocyte ratio
(NLR) and the risk of all-cause mortality or cardiovascular events in patients with chronic …

Vitamin K and cardiovascular complications in chronic kidney disease patients

N Kaesler, LJ Schurgers, J Floege - Kidney International, 2021 - Elsevier
Vitamin K, well known for its role in coagulation, encompasses 2 major subgroups: vitamin
K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial …

[HTML][HTML] Vitamin K and D supplementation and bone health in chronic kidney disease—apart or together?

M Ziemińska, B Sieklucka, K Pawlak - Nutrients, 2021 - mdpi.com
Vitamin K (VK) and vitamin D (VD) deficiency/insufficiency is a common feature of chronic
kidney disease (CKD), leading to impaired bone quality and a higher risk of fractures. CKD …

[HTML][HTML] Randomized controlled clinical trial of the effect of treatment with vitamin K2 on vascular calcification in hemodialysis patients (Trevasc-HDK)

S Haroon, A Davenport, LH Ling, BC Tai… - Kidney international …, 2023 - Elsevier
Introduction Vitamin K deficiency among patients on hemodialysis (HD) affects the function
of matrix GLA protein (MGP), a potent vitamin K-dependent inhibitor of vascular calcification …