Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis.
Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative …

Background and Aims RNA-based, antibody-based, and genome editing-based therapies
are currently under investigation to determine if the inhibition of angiopoietin-like protein-3 …

Bipolar disorder (BD) is a complex mood disorder with a strong genetic component. Recent
studies suggest that microRNAs contribute to psychiatric disorder development. In BD …

Nearly two hundred common-variant depression risk loci have been identified by genome-
wide association studies (GWAS). However, the impact of rare coding variants on …

Psychotic and affective disorders often aggregate in the relatives of probands with
schizophrenia, and genetic studies show substantial genetic correlation among …

While numerous genomic loci have been identified for neuropsychiatric conditions, the
contribution of protein-coding variants has yet to be determined. Here we conducted a large …

Genomic regulatory elements active in the developing human brain are notably enriched in
genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) …

Due to alternative splicing, human protein-coding genes average over eight RNA isoforms,
resulting in nearly four distinct protein coding sequences per gene. Long-read RNAseq …

Bipolar disorder (BD) is a common mental disorder characterized by recurrent mood
episodes, which causes major socioeconomic burdens globally. Though its disease …

Bipolar disorder is a severe neuro-psychiatric condition where genome-wide association
and sequencing studies have pointed to dysregulated gene expression as likely to be …