[HTML][HTML] DRD2, DRD3, and HTR2A single-nucleotide polymorphisms involvement in high treatment resistance to atypical antipsychotic drugs
Background: The objective of this study was to investigate the DRD2 rs1800497, rs1799732,
rs1801028, DRD3 rs6280, and HTR2A rs6314, rs7997012, and rs6311 single-nucleotide …
rs1801028, DRD3 rs6280, and HTR2A rs6314, rs7997012, and rs6311 single-nucleotide …
[HTML][HTML] CaMKK2 as an emerging treatment target for bipolar disorder
J Kaiser, K Nay, CR Horne, LM McAloon… - Molecular …, 2023 - nature.com
Current pharmacological treatments for bipolar disorder are inadequate and based on
serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and …
serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and …
[HTML][HTML] Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families
M Ahangari, AE Gentry, TH Nguyen… - Translational …, 2022 - nature.com
Multiplex families have higher recurrence risk of schizophrenia compared to the families of
sporadic cases, but the source of this increased recurrence risk is unknown. We used …
sporadic cases, but the source of this increased recurrence risk is unknown. We used …
Against theory-motivated experimentation in science
Scientists must choose which among many experiments to perform. We study the epistemic
success of experimental choice strategies proposed by philosophers of science or executed …
success of experimental choice strategies proposed by philosophers of science or executed …
Genetic inhibition of angiopoietin-like protein-3, lipoprotein-lipid levels and cardiometabolic diseases
É Gobeil, J Bourgault, PL Mitchell, U Houessou… - medRxiv, 2023 - medrxiv.org
Background: RNA-based, antibody-based and gene editing-based therapies are currently
under investigation to determine if the inhibition of angiopoietin-like protein-3 (ANGPTL3) …
under investigation to determine if the inhibition of angiopoietin-like protein-3 (ANGPTL3) …
[HTML][HTML] Prioritizing genes associated with brain disorders by leveraging enhancer-promoter interactions in diverse neural cells and tissues
Background Prioritizing genes that underlie complex brain disorders poses a considerable
challenge. Despite previous studies have found that they shared symptoms and …
challenge. Despite previous studies have found that they shared symptoms and …
[HTML][HTML] Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia
Genetic studies in psychiatry have primarily focused on the effects of common genetic
variants, but few have investigated the role of rare genetic variants, particularly for major …
variants, but few have investigated the role of rare genetic variants, particularly for major …
[HTML][HTML] The Biology of Mental Disorders: Progress at Last
SE Hyman - Dædalus, 2023 - direct.mit.edu
Mental disorders are common, complex, highly morbid conditions for which basic underlying
mechanisms are poorly understood. Despite the utility of many existing treatments, there …
mechanisms are poorly understood. Despite the utility of many existing treatments, there …
Cell-type-specificity of isoform diversity in the developing human neocortex informs mechanisms of neurodevelopmental disorders
Human brain development is under tight molecular genetic control and the recent advent of
single-cell genomics has revolutionized our ability to elucidate the diverse underlying cell …
single-cell genomics has revolutionized our ability to elucidate the diverse underlying cell …
[HTML][HTML] Unraveling the interplay of circadian rhythm and sleep deprivation on mood: A Real-World Study on first-year physicians
The interplay between circadian rhythms, time awake, and mood remains poorly understood
in the real-world. Individuals in high-stress occupations with irregular schedules or nighttime …
in the real-world. Individuals in high-stress occupations with irregular schedules or nighttime …