Alternative splicing is a post-transcriptional mechanism that increases the diversity of
expressed transcripts and plays an important role in regulating gene expression in the …

The gene A-kinase anchoring protein 11 (AKAP11) recently emerged as a shared risk factor
between bipolar disorder and schizophrenia, driven by large-effect loss-of-function (LoF) …

The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated
gene in autism spectrum disorder. Despite its prominent disease involvement, little is known …

Long range projection neurons of the cerebral cortex provide multimodal integration via
connectivity between distant areas of the brain, thus are critical for sensory integration, motor …

Background: The degree of gene and sequence preservation across species provides
valuable insights into the relative necessity of genes from the perspective of natural …

The past years have been an incredibly exciting time in the field of psychiatric genetics.
Technological and methodological advances, coupled with significant increases in sample …

Autophagy is a catabolic and self-degradative process crucial for maintaining cellular
homeostasis. Malfunctional autophagy is implicated in neurodevelopmental and …

Abstract Intrinsically Disordered Proteins (IDPs) play crucial roles in signal transduction, cell
differentiation, and transcriptional regulation. Many disrupted genes associated with mental …

Bipolar disorder (BD) is a severe mental illness that can result from neurodevelopmental
aberrations, particularly in familial BD, which may include causative genetic variants. In the …

Bipolar disorder (BD) is a debilitating disorder affecting~ 1% of the world's population.
Although many common and some rare alleles are associated with this complex disorder …