Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed
cause of ageing is the accumulation of epigenetic noise that disrupts gene expression …

Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …

Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

Recent research efforts provided compelling evidence of genome-wide DNA methylation
alterations in aging and age-related disease. It is currently well established that DNA …