Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …

B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …

Abstract Characterization and integration of the genome, epigenome, transcriptome,
proteome and metabolome of different datasets is difficult owing to a lack of ground truth …

Single-cell methodologies and technologies have started a revolution in biology which until
recently has primarily been limited to deep sequencing and imaging modalities. With the …

Sex differences are found across brain regions, behaviors, and brain diseases. Sexual
differentiation of the brain is initiated prenatally but it continues throughout life, as a result of …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of
immunological defense against inhaled or ingested pathogens. We generated an atlas of …

International efforts are underway to provide a comprehensive survey of cells across the
human life span (,). These efforts assign cell “types” on the basis of a set of information-rich …

Understanding how HIV-1-infected cells proliferate and persist is key to HIV-1 eradication,
but the heterogeneity and rarity of HIV-1-infected cells hamper mechanistic interrogations …

Assigning functions to genes and learning how to control their expression are part of the
foundation of cell biology and therapeutic development. An efficient and unbiased method to …