CRISPR ethics: moral considerations for applications of a powerful tool
C Brokowski, M Adli - Journal of molecular biology, 2019 - Elsevier
With the emergence of CRISPR technology, targeted editing of a wide variety of genomes is
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …
no longer an abstract hypothetical, but occurs regularly. As application areas of CRISPR are …
CRISPR-Cas system: an approach with potentials for COVID-19 diagnosis and therapeutics
COVID-19, the human coronavirus disease caused by SARS-CoV-2, was reported for the
first time in Wuhan, China in late 2019. COVID-19 has no preventive vaccine or proven …
first time in Wuhan, China in late 2019. COVID-19 has no preventive vaccine or proven …
Variability in genome editing outcomes: challenges for research reproducibility and clinical safety
Genome editing tools have already revolutionized biomedical research and are also
expected to have an important impact in the clinic. However, their extensive use in research …
expected to have an important impact in the clinic. However, their extensive use in research …
Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection
The CRISPR/Cas9 gene-editing approach has been widely used in anti-HIV-1 gene therapy
research. However, the major challenges facing the therapeutic application of CRISPR/Cas9 …
research. However, the major challenges facing the therapeutic application of CRISPR/Cas9 …
An all-in-one nanomedicine consisting of CRISPR-Cas9 and an autoantigen peptide for restoring specific immune tolerance
YL Luo, LF Liang, YJ Gan, J Liu, Y Zhang… - … Applied Materials & …, 2020 - ACS Publications
Nanotechnology has shown great promise in treating diverse diseases. However,
developing nanomedicines that can cure autoimmune diseases without causing systemic …
developing nanomedicines that can cure autoimmune diseases without causing systemic …
Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV
G Di Liberto, K Egervari, M Kreutzfeldt, CM Schürch… - Brain, 2022 - academic.oup.com
Glial cell activation is a hallmark of several neurodegenerative and neuroinflammatory
diseases. During HIV infection, neuroinflammation is associated with cognitive impairment …
diseases. During HIV infection, neuroinflammation is associated with cognitive impairment …
[HTML][HTML] SARS-CoV-2 pandemics: an update of CRISPR in diagnosis and host–virus interaction studies
Abstract Since December 2019, the Coronavirus disease 2019 (COVID-19) outbreak caused
by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread rapidly …
by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread rapidly …
Gene therapy for pancreatic cancer: specificity, issues and hopes
M Rouanet, M Lebrin, F Gross, B Bournet… - International journal of …, 2017 - mdpi.com
A recent death projection has placed pancreatic ductal adenocarcinoma as the second
cause of death by cancer in 2030. The prognosis for pancreatic cancer is very poor and …
cause of death by cancer in 2030. The prognosis for pancreatic cancer is very poor and …
Nanosystems applied to HIV infection: prevention and treatments
MA Macchione, D Aristizabal Bedoya… - International journal of …, 2020 - mdpi.com
Sexually-transmitted infections (STIs) are a global health concern worldwide as they cause
acute diseases, infertility, and significant mortality. Among the bacterial, viral, and parasitic …
acute diseases, infertility, and significant mortality. Among the bacterial, viral, and parasitic …
Recent advances in mammalian reproductive biology
Reproductive biology is a uniquely important topic since it is about germ cells, which are
central for transmitting genetic information from generation to generation. In this review, we …
central for transmitting genetic information from generation to generation. In this review, we …