Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …

Single-cell RNA sequencing (scRNA-seq) has become an empowering technology to profile
the transcriptomes of individual cells on a large scale. Early analyses of differential …

In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …

Single-cell transcriptomics can profile thousands of cells in a single experiment and identify
novel cell types, states and dynamics in a wide variety of tissues and organisms. Standard …

Fueled by recent advances in single cell biology, we are moving away from qualitative and
undersampled assessments of cell identity, toward building quantitative, high-resolution cell …

With growing populations and pressing environmental problems, future economies will be
increasingly plant-based. Now is the time to reimagine plant science as a critical component …

Invariant cell lineage in C. elegans enables spatiotemporal resolution of transcriptional
regulatory mechanisms controlling the fate of each cell. Here, we develop RAPCAT (Robust …

The kidney is among the most complex organs in terms of the variety of cell types. The
cellular complexity of human kidneys is not fully unraveled and this challenge is further …