It has been more than three decades since the first monoclonal antibody was approved by
the United States Food and Drug Administration (US FDA) in 1986, and during this time …

Last decade witnessed the outbreak of many life-threatening human pathogens including
Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS …

Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV)
infection which is often limited to a febrile illness, but may lead to very aggressive …

Background The discovery of potent and broadly neutralizing antibodies (bNAbs) against
human immunodeficiency virus (HIV) has made passive immunization a potential strategy …

Opinion statement Dengue viruses (DENV) continue to circulate worldwide, resulting in a
significant burden on human health. There are four antigenically distinct serotypes of DENV …

Generative machine learning (ML) has been postulated to become a major driver in the
computational design of antigen-specific monoclonal antibodies (mAb). However, efforts to …

Coronaviruses (CoVs) are a group of viruses from the family Coronaviridae that can infect
humans and animals, causing mild to severe diseases. The ongoing pandemic of severe …

Influenza virus remains a serious health threat, owing to its ability to evade immune
surveillance through rapid genetic drift and reassortment. Here we used a human non …

Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate
severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We …

Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the
challenges of siRNA delivery and lack of suitable animal models. Using a delivery method …