Immunologic effects of vitamin D on human health and disease

N Charoenngam, MF Holick - Nutrients, 2020 - mdpi.com
Vitamin D is responsible for regulation of calcium and phosphate metabolism and
maintaining a healthy mineralized skeleton. It is also known as an immunomodulatory …

The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

JJ Hu, X Liu, S Xia, Z Zhang, Y Zhang, J Zhao… - Nature …, 2020 - nature.com
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells
assembles large complexes called inflammasomes, which activate inflammatory caspases …

[PDF][PDF] Sepsis and septic shock: Guideline-based management

S Dugar, C Choudhary, A Duggal - Cleve Clin J Med, 2020 - christopherreeve.org
Sepsis is a life-threatening organ dysfunction that results from the body's response to
infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic …

COVID-19 and Sepsis

ZK Tufan, B Kayaaslan, M Mer - Turkish journal of medical …, 2021 - journals.tubitak.gov.tr
The COVID-19 pandemic has created a major alteration in the medical literature including
the sepsis discussion. From the outset of the pandemic, various reports have indicated that …

Vitamin D and its potential benefit for the COVID-19 pandemic

N Charoenngam, A Shirvani, MF Holick - Endocrine Practice, 2021 - Elsevier
Vitamin D is known not only for its importance for bone health but also for its biologic
activities on many other organ systems. This is due to the presence of the vitamin D receptor …

Prognostic value of platelet to lymphocyte ratio in sepsis: a systematic review and meta‐analysis

G Wang, A Mivefroshan, S Yaghoobpoor… - BioMed Research …, 2022 - Wiley Online Library
The goal of this study was to conduct a systematic review of the literature on the relationship
between peripheral blood platelet to lymphocyte ratio (PLR) and mortality in sepsis and to …

Sepsis: diagnosis and management

R Gauer, D Forbes, N Boyer - American family physician, 2020 - aafp.org
Guidelines published in 2016 provide a revised definition of sepsis: life-threatening organ
dysfunction caused by a dysregulated host response to infection. The guidelines define …

Sestrin2 protects dendrite cells against ferroptosis induced by sepsis

J Li, C Ren, LX Wang, R Yao, N Dong, Y Wu… - Cell Death & …, 2021 - nature.com
Ferroptosis is a nonapoptotic form of programmed cell death triggered by the accumulation
of reactive oxygen species (ROS) depended on iron overload. Although most investigations …

Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside

Z Doganyigit, E Eroglu, E Akyuz - Human & experimental …, 2022 - journals.sagepub.com
Background: Sepsis is a serious clinical condition characterized by damage to the immune
system as a result of an uncontrolled response to infection. Septic patients show …