[HTML][HTML] METTL3 Attenuates Inflammation in Fusarium solani–Induced Keratitis via the PI3K/AKT Signaling Pathway

L Huang, H Tang, J Hu - Investigative Ophthalmology & Visual …, 2022 - tvst.arvojournals.org
Purpose: Our previous investigations revealed a significant role of methyltransferase-like 3
(METTL3)-mediated N6-methyladenosine (m 6 A) modification in the development of …

[HTML][HTML] Construction and validation of a cuproptosis-related lncRNA signature for the prediction of the prognosis of LUAD and LUSC

Y Wang, X Xiao, Y Li - Scientific Reports, 2023 - nature.com
Lung cancer is one of the most prevalent malignant tumors worldwide, with lung
adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) accounting for the …

Unveiling the molecular features, relevant immune and clinical characteristics of SIGLEC15 in thyroid cancer

X Hou, C Chen, X Lan, X He - Frontiers in Immunology, 2022 - frontiersin.org
The groundbreaking research work about SIGLEC15 has raised it as a potential promising
target in cancer immunotherapy. Unfortunately, the role of SIGLEC15 in thyroid carcinoma …

m6A-related bioinformatics analysis and functional characterization reveals that METTL3-mediated NPC1L1 mRNA hypermethylation facilitates progression of …

G Zhang, X Li, X Huang - Inflammation Research, 2023 - Springer
Objective Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays
important roles in many major diseases, including atherosclerosis (AS). In the present study …

m6ACali: machine learning-powered calibration for accurate m6A detection in MeRIP-Seq

H Ye, T Li, DJ Rigden, Z Wei - Nucleic Acids Research, 2024 - academic.oup.com
We present m6ACali, a novel machine-learning framework aimed at enhancing the accuracy
of N6-methyladenosine (m6A) epitranscriptome profiling by reducing the impact of non …

mRNA processing: an emerging frontier in the regulation of pancreatic β cell function

ND Moss, L Sussel - Frontiers in Genetics, 2020 - frontiersin.org
Robust endocrine cell function, particularly β cell function, is required to maintain blood
glucose homeostasis. Diabetes can result from the loss or dysfunction of β cells. Despite …

[HTML][HTML] Identification of m5C-related molecular subtypes and prediction models in the prognosis and tumor microenvironment infiltration of soft tissue sarcoma

X Wang, Y Mao, H Xu, J Chen - Heliyon, 2023 - cell.com
Background The epigenetic regulator in cancer progression and immune response has
been demonstrated recently. However, the potential implications of 5-methylcytosine (m 5 C) …

Molecular mechanism analysis of m6A modification-related lncRNA-miRNA-mRNA network in regulating autophagy in acute pancreatitis

X Li, H Qin, A Anwar, X Zhang, F Yu, Z Tan, Z Tang - Islets, 2022 - Taylor & Francis
This study aims to explore the molecular mechanism of N6-methyladenosine (m6A)
modification-related long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger RNA …

Potential diabetic cardiomyopathy therapies targeting pyroptosis: A mini review

Y Jia, D Li, J Yu, W Jiang, X Liao… - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Pyroptosis is primarily considered a pro-inflammatory class of caspase-1-and gasdermin D
(GSDMD)-dependent programmed cell death. Inflammasome activation promotes the …

Fusarium infection alters the m6A-modified transcript landscape in the cornea

J Hu, Y Lin - Experimental Eye Research, 2020 - Elsevier
Abstract N6-methyladenosine (m 6 A) is the most common post-transcriptional modification
of RNA in eukaryotes that regulates the post-transcriptional expression level of genes …