M6A regulatory genes play an important role in the prognosis, progression and immune microenvironment of pancreatic adenocarcinoma

F Xu, Z Zhang, M Yuan, Y Zhao, Y Zhou, H Pei… - Cancer …, 2021 - Taylor & Francis
The specific roles of N6-methyladenosine (m6A) regulatory genes in pancreatic
adenocarcinoma (PAAD) have not been fully elucidated. In present study, a novel risk …

[HTML][HTML] An emerging role of m6A in memory: a case for translational priming

AM Leonetti, MY Chu, FO Ramnaraign, S Holm… - International journal of …, 2020 - mdpi.com
Investigation into the role of methylation of the adenosine base (m6A) of RNA has only
recently begun, but it quickly became apparent that m6A is able to control and fine-tune …

METTL3 achieves lipopolysaccharide-induced myocardial injury via m6A-dependent stabilization of Myh3 mRNA

C Gong, J Wu, H Li, C Luo, G Ji, X Guan, J Liu… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Septic cardiomyopathy (SCM) was an important pathological component of severe sepsis
and septic shock. N6-methyladenosine (m 6 A) modification was a common RNA …

Methyltransferase‐like 3‐mediated N6‐methyladenosine modification of miR‐7212‐5p drives osteoblast differentiation and fracture healing

B Mi, Y Xiong, C Yan, L Chen, H Xue… - Journal of Cellular …, 2020 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) modification has been reported in various diseases
and implicated in increasing numbers of biological processes. However, previous studies …

[HTML][HTML] m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision …

B Chen, Y Xi, J Zhao, Y Hong, S Tian, X Zhai… - Frontiers in …, 2022 - frontiersin.org
Background The RNA modification 5-methylcytosine (m5C) is one of the most prevalent post-
transcriptional modifications, with increasing evidence demonstrating its extensive …

[HTML][HTML] Long non-coding RNA epigenetics

M Kazimierczyk, J Wrzesinski - International Journal of Molecular …, 2021 - mdpi.com
Long noncoding RNAs exceeding a length of 200 nucleotides play an important role in
ensuring cell functions and proper organism development by interacting with cellular …

[HTML][HTML] Emerging role of epitranscriptomics in diabetes mellitus and its complications

X Geng, Z Li, Y Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetes mellitus (DM) and its related complications are among the leading causes of
disability and mortality worldwide. Substantial studies have explored epigenetic regulation …

[HTML][HTML] Pan-Cancer Molecular Characterization of m6A Regulators and Immunogenomic Perspective on the Tumor Microenvironment

J Zhu, J Xiao, M Wang, D Hu - Frontiers in Oncology, 2021 - frontiersin.org
Purpose N6-methyladenosine (m6A) methylation plays a critical role in diverse biological
processes. However, knowledge regarding the constitution of m6A on tumor …

[HTML][HTML] Recent advances of m6A methylation modification in esophageal squamous cell carcinoma

X Zhang, N Lu, L Wang, Y Wang, M Li, Y Zhou… - Cancer cell …, 2021 - Springer
In recent years, with the development of RNA sequencing technology and bioinformatics
methods, the epigenetic modification of RNA based on N6-methyladenosine (m6A) has …

[HTML][HTML] N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis

A Quiles-Jiménez, I Gregersen, MML de Sousa… - Biochemical and …, 2020 - Elsevier
Background More than 170 post-transcriptional RNA modifications regulate the localization,
processing and function of cellular RNAs, and aberrant RNA modifications have been linked …