[HTML][HTML] Towards accurate and reliable resolution of structural variants for clinical diagnosis

Z Liu, R Roberts, TR Mercer, J Xu, FJ Sedlazeck… - Genome biology, 2022 - Springer
Structural variants (SVs) are a major source of human genetic diversity and have been
associated with different diseases and phenotypes. The detection of SVs is difficult, and a …

[HTML][HTML] The Allen Ancient DNA Resource (AADR) a curated compendium of ancient human genomes

S Mallick, A Micco, M Mah, H Ringbauer, I Lazaridis… - Scientific Data, 2024 - nature.com
More than two hundred papers have reported genome-wide data from ancient humans.
While the raw data for the vast majority are fully publicly available testifying to the …

[PDF][PDF] Hunter-gatherer genomes reveal diverse demographic trajectories during the rise of farming in Eastern Africa

S Gopalan, REW Berl, JW Myrick, ZH Garfield… - Current Biology, 2022 - cell.com
The fate of hunting and gathering populations following the rise of agriculture and
pastoralism remains a topic of debate in the study of human prehistory. Studies of ancient …

An efficient method to identify, date, and describe admixture events using haplotype information

P Wangkumhang, M Greenfield, G Hellenthal - Genome research, 2022 - genome.cshlp.org
We present fastGLOBETROTTER, an efficient new haplotype-based technique to identify,
date, and describe admixture events using genome-wide autosomal data. With simulations …

Javelin use among Ethiopia's last indigenous hunters: Variability and further constraints on tip cross-sectional geometry

Y Sahle, S Ahmed, SJ Dira - Journal of Anthropological Archaeology, 2023 - Elsevier
Ethnographically known weapon systems are crucial for the functional interpretation of
pertinent archaeological materials. The tip cross-sectional geometries of North American …

Three assays for in-solution enrichment of ancient human DNA at more than a million SNPs

N Rohland, S Mallick, M Mah, R Maier… - Genome …, 2022 - genome.cshlp.org
The strategy of in-solution enrichment for hundreds of thousands of single-nucleotide
polymorphisms (SNPs) has been used to analyze> 70% of individuals with genome-scale …

[HTML][HTML] Immunohistochemistry-derived subtypes of breast cancer distribution in four regions of Ethiopia

EB Belachew, AF Desta, TY Gebremariam… - Frontiers in …, 2023 - frontiersin.org
Purpose Different biological characteristics, therapeutic responses, and disease-specific
outcomes are associated with different molecular subtypes of breast cancer (BC). Although …

Medieval DNA from Soqotra points to Eurasian origins of an isolated population at the crossroads of Africa and Arabia

K Sirak, J Jansen Van Rensburg, E Brielle… - Nature Ecology & …, 2024 - nature.com
Soqotra, an island situated at the mouth of the Gulf of Aden in the northwest Indian Ocean
between Africa and Arabia, is home to~ 60,000 people subsisting through fishing and semi …

[PDF][PDF] Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa

EG Atkinson, S Dalvie, Y Pichkar, A Kalungi… - The American Journal of …, 2022 - cell.com
African populations are the most diverse in the world yet are sorely underrepresented in
medical genetics research. Here, we examine the structure of African populations using …

[HTML][HTML] Whole genomes from Angola and Mozambique inform about the origins and dispersals of major African migrations

S Tallman, MD Sungo, S Saranga, S Beleza - Nature Communications, 2023 - nature.com
As the continent of origin for our species, Africa harbours the highest levels of diversity
anywhere on Earth. However, many regions of Africa remain under-sampled genetically …