The transition to compulsion in addiction

C Lüscher, TW Robbins, BJ Everitt - Nature Reviews Neuroscience, 2020 - nature.com
Compulsion is a cardinal symptom of drug addiction (severe substance use disorder).
However, compulsion is observed in only a small proportion of individuals who repeatedly …

Three aspects of representation in neuroscience

B Baker, B Lansdell, KP Kording - Trends in cognitive sciences, 2022 - cell.com
Neuroscientists often describe neural activity as a representation of something, or claim to
have found evidence for a neural representation, but there is considerable ambiguity about …

Meta-reinforcement learning via orbitofrontal cortex

R Hattori, NG Hedrick, A Jain, S Chen, H You… - Nature …, 2023 - nature.com
The meta-reinforcement learning (meta-RL) framework, which involves RL over multiple
timescales, has been successful in training deep RL models that generalize to new …

The role of population structure in computations through neural dynamics

A Dubreuil, A Valente, M Beiran… - Nature …, 2022 - nature.com
Neural computations are currently investigated using two separate approaches: sorting
neurons into functional subpopulations or examining the low-dimensional dynamics of …

[HTML][HTML] Thalamus-driven functional populations in frontal cortex support decision-making

W Yang, SL Tipparaju, G Chen, N Li - Nature neuroscience, 2022 - nature.com
Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and
cognitive variables during decision-making. The neural circuit basis for this complex …

Evolving schema representations in orbitofrontal ensembles during learning

J Zhou, C Jia, M Montesinos-Cartagena, MPH Gardner… - Nature, 2021 - nature.com
How do we learn about what to learn about? Specifically, how do the neural elements in our
brain generalize what has been learned in one situation to recognize the common structure …

The orbitofrontal cortex maps future navigational goals

R Basu, R Gebauer, T Herfurth, S Kolb, Z Golipour… - Nature, 2021 - nature.com
Accurate navigation to a desired goal requires consecutive estimates of spatial relationships
between the current position and future destination throughout the journey. Although …

Goals, usefulness and abstraction in value-based choice

B De Martino, A Cortese - Trends in Cognitive Sciences, 2023 - cell.com
Abstract Colombian drug lord Pablo Escobar, while on the run, purportedly burned two
million dollars in banknotes to keep his daughter warm. A stark reminder that, in life …

Circuit-specific gene therapy reverses core symptoms in a primate Parkinson's disease model

Y Chen, Z Hong, J Wang, K Liu, J Liu, J Lin, S Feng… - Cell, 2023 - cell.com
Parkinson's disease (PD) is a debilitating neurodegenerative disorder. Its symptoms are
typically treated with levodopa or dopamine receptor agonists, but its action lacks specificity …

The implications of categorical and category-free mixed selectivity on representational geometries

MT Kaufman, MK Benna, M Rigotti, F Stefanini… - Current opinion in …, 2022 - Elsevier
The firing rates of individual neurons displaying mixed selectivity are modulated by multiple
task variables. When mixed selectivity is nonlinear, it confers an advantage by generating a …