Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19

RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

SARS‐CoV‐2, aging, and Post‐COVID‐19 neurodegeneration

MJ Strong - Journal of Neurochemistry, 2023 - Wiley Online Library
As the world continues to experience the effects of SARS‐CoV‐2, there is evidence to
suggest that the sequelae of viral infection (the post‐COVID‐19 condition; PCC) at both an …

Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients

M Khan, M Clijsters, S Choi, W Backaert, M Claerhout… - Neuron, 2022 - cell.com
Can SARS-CoV-2 hitchhike on the olfactory projection and take a direct and short route from
the nose into the brain? We reasoned that the neurotropic or neuroinvasive capacity of the …

Virus diversity, wildlife-domestic animal circulation and potential zoonotic viruses of small mammals, pangolins and zoo animals

X Cui, K Fan, X Liang, W Gong, W Chen, B He… - Nature …, 2023 - nature.com
Wildlife is reservoir of emerging viruses. Here we identified 27 families of mammalian
viruses from 1981 wild animals and 194 zoo animals collected from south China between …

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

M Lavigne, O Helynck, P Rigolet… - Nucleic acids …, 2021 - academic.oup.com
The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by
coronavirus (CoV) genomes and several regions of this protein are essential for viral …

Discovery and crystallographic studies of nonpeptidic piperazine derivatives as covalent SARS-CoV-2 main protease inhibitors

S Gao, L Song, T Claff, M Woodson… - Journal of Medicinal …, 2022 - ACS Publications
The spread of SARS-CoV-2 keeps threatening human life and health, and small-molecule
antivirals are in demand. The main protease (Mpro) is an effective and highly conserved …

Electrical detection assay based on programmable nucleic acid probe for efficient single-nucleotide polymorphism identification

Y Zhang, B Chen, D Chen, Y Wang, Q Lu, J Tan… - ACS …, 2023 - ACS Publications
The large-scale pandemic and fast evolution of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variants have triggered an urgent need for an efficient and …

Structural basis for the inhibition of coronaviral main proteases by ensitrelvir

C Lin, H Jiang, W Li, P Zeng, X Zhou, J Zhang, J Li - Structure, 2023 - cell.com
Main protease (M pro) is a highly conserved cysteine protease that plays a vital role in the
replication of coronaviruses, making it an attractive pan-coronaviral therapeutic target …

Antibacterial and Antiviral Activities of Silver Nanocluster/Silica Composite Coatings Deposited onto Air Filters

A Luceri, R Francese, S Perero, D Lembo… - … Applied Materials & …, 2024 - ACS Publications
The indoor air quality should be better controlled and improved to avoid numerous health
issues. Even if different devices are developed for air filtration, the proliferation of …

Heterotypic immunity from prior SARS-CoV-2 infection but not COVID-19 vaccination associates with lower endemic coronavirus incidence

DJ Bean, J Monroe, YM Liang, E Borberg… - Science Translational …, 2024 - science.org
Immune responses from prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection and COVID-19 vaccination mitigate disease severity, but they do not fully prevent …