IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, with
diverse clinical manifestations characterized by recurrent gross hematuria or microscopic …

Background T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context
of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 …

Progressive weight loss combined with skeletal muscle atrophy, termed cachexia, is a
common comorbidity associated with cancer that results in adverse consequences for the …

Selective inhibitors targeting the first bromodomain (BD1) or the second bromodomain
(BD2) of the bromodomain and extra terminal domain (BET) proteins have triggered …

Sepsis is well known to cause a high patient death rate (up to 50%) during the intensive care
unit (ICU) stay. In addition, sepsis survival patients also exhibit a very high death rate after …

Th17 cells are involved in rheumatoid arthritis (RA) pathogenesis. Our previous studies have
revealed that transcription factor Yin Yang 1 (YY1) plays an important role in the pathogenic …

Th17 cells are recognized as indispensable in inducing protective immunity against bacteria
and fungi, as they promote the integrity of mucosal epithelial barriers. It is believed that Th17 …

Background Periodontitis is a multifactorial inflammatory disease mediated by the host
immune response to dental plaque. Periodontitis is characterized by periodontal bone loss …

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in
childhood. The disease etiology remains largely unknown; however, a key role in JIA …

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), leads to the dysregulation of the immune system …