The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Background Pancreatic cancer is one of the most lethal malignancies and has an extremely
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …

The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Breast cancer is a complex and diverse condition that disrupts multiple signaling pathways
essential for cell proliferation, survival, and differentiation. Recently, the significant …

Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC‐related
mortality, and is typically caused by interactions between CRC cells and the tumour …

CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of
species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt …

Long non-coding RNAs (lncRNAs), a novel class of noncoding RNAs, are commonly defined
as RNA molecules more than 200 nucleotides in length. Emerging research indicated that …

In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

Background Trastuzumab resistance followed by metastasis is a major obstacle for
improving the clinical outcome of patients with advanced human epidermal growth factor …