Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer
To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein
kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent …
kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent …
A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer
A Singhal, HC Styers, J Rub, Z Li, SR Torborg… - Cancer …, 2024 - aacrjournals.org
Intra-tumoral heterogeneity in pancreatic ductal adenocarcinoma (PDAC) is characterized
by a balance between basal and classical epithelial cancer cell states, with basal …
by a balance between basal and classical epithelial cancer cell states, with basal …
Reporter-based screening identifies RAS-RAF stabilizing mutations as drivers of resistance to broad-spectrum RAS inhibition in colorectal cancer
O Aust, E Blanc, M Lüthen, V Hollek… - bioRxiv, 2024 - biorxiv.org
Secondary resistance limits the clinical effectiveness of mutation-specific RAS inhibitors in
colorectal cancer. It is unknown whether broad-spectrum RAS inhibitors meet similar …
colorectal cancer. It is unknown whether broad-spectrum RAS inhibitors meet similar …