Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Ocular neurodegenerative diseases: interconnection between retina and cortical areas

N Marchesi, F Fahmideh, F Boschi, A Pascale… - Cells, 2021 - mdpi.com
The possible interconnection between the eye and central nervous system (CNS) has been
a topic of discussion for several years just based on fact that the eye is properly considered …

Retinal pathological features and proteome signatures of Alzheimer's disease

Y Koronyo, A Rentsendorj, N Mirzaei, GC Regis… - Acta …, 2023 - Springer
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Retinal vasculopathy in Alzheimer's disease

H Shi, Y Koronyo, A Rentsendorj, DT Fuchs… - Frontiers in …, 2021 - frontiersin.org
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies

FJ Hart de Ruyter, THJ Morrema, J den Haan… - Acta …, 2023 - Springer
The retina is a potential source of biomarkers for the detection of neurodegenerative
diseases. Accumulation of phosphorylated tau (p-tau) in the brain is a pathological feature …

[HTML][HTML] Small-molecule theranostics in Alzheimer's disease

Á Sarabia-Vallejo, P López-Alvarado… - European Journal of …, 2023 - Elsevier
Alzheimer's Disease (AD) remains one of the most challenging health-related issues for our
society. It is becoming increasingly prevalent, especially in developed countries, due to the …

Automatic segmentation of retinal layers in multiple neurodegenerative disorder scenarios

M Gende, V Mallen, J de Moura… - IEEE Journal of …, 2023 - ieeexplore.ieee.org
Retinal Optical Coherence Tomography (OCT) allows the non-invasive direct observation of
the central nervous system, enabling the measurement and extraction of biomarkers from …

Proteostasis in aging-associated ocular disease

J Weinberg, M Gaur, A Swaroop, A Taylor - Molecular aspects of medicine, 2022 - Elsevier
Vision impairment has devastating consequences for the quality of human life. The cells and
tissues associated with the visual process must function throughout one's life span and …

Müller cell degeneration and microglial dysfunction in the Alzheimer's retina

QA Xu, P Boerkoel, V Hirsch-Reinshagen… - Acta Neuropathologica …, 2022 - Springer
Amyloid beta (Aβ) deposits in the retina of the Alzheimer's disease (AD) eye may provide a
useful diagnostic biomarker for AD. This study focused on the relationship of Aβ with …