Tobacco product use and the risks of SARS-CoV-2 infection and COVID-19: current understanding and recommendations for future research

NL Benowitz, ML Goniewicz… - The Lancet …, 2022 - thelancet.com
Heterogeneity in the clinical presentation of SARS-CoV-2 infection and COVID-19
progression underscores the urgent need to identify individual-level susceptibility factors …

Mechanisms governing anaphylaxis: inflammatory cells, mediators, endothelial gap junctions and beyond

SMT Nguyen, CP Rupprecht, A Haque… - International journal of …, 2021 - mdpi.com
Anaphylaxis is a severe, acute, life-threatening multisystem allergic reaction resulting from
the release of a plethora of mediators from mast cells culminating in serious respiratory …

Role of p38 mitogen‐activated protein kinase signalling in virus replication and potential for developing broad spectrum antiviral drugs

Y Chander, R Kumar, N Khandelwal… - Reviews in Medical …, 2021 - Wiley Online Library
Mitogen‐activated protein kinases (MAPKs) play a key role in complex cellular processes
such as proliferation, development, differentiation, transformation and apoptosis. Mammals …

A timely call to arms: COVID-19, the circadian clock, and critical care

J Haspel, M Kim, P Zee… - Journal of biological …, 2021 - journals.sagepub.com
We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19)
pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory …

Comparing the cytokine storms of COVID-19 and pandemic influenza

LM Pacheco-Hernández… - Journal of interferon & …, 2022 - liebertpub.com
Emerging respiratory viruses are major health threats due to their potential to cause massive
outbreaks. Over the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has …

A validated mathematical model of the cytokine release syndrome in severe COVID-19

RF Reis, AB Pigozzo, CRB Bonin… - Frontiers in molecular …, 2021 - frontiersin.org
By June 2021, a new contagious disease, the Coronavirus disease 2019 (COVID-19), has
infected more than 172 million people worldwide, causing more than 3.7 million deaths …

Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism

L Li, W Xu, Y Luo, C Lao, X Tong, J Du, B Huang… - Carbohydrate …, 2022 - Elsevier
The cytokine storm is highly associated with inflammatory-type disease severity and patients'
survival. Plant polysaccharides, the main natural phytomedicine source, have a great …

The potential role of cytokine storm pathway in the clinical course of viral respiratory pandemic

G Murdaca, F Paladin, A Tonacci, S Isola, A Allegra… - Biomedicines, 2021 - mdpi.com
The “cytokine storm”(CS) consists of a spectrum of different immune dysregulation disorders
characterized by constitutional symptoms, systemic inflammation and multiorgan dysfunction …

Fostering experimental and computational synergy to modulate hyperinflammation

I Potapov, TD Kanneganti, A Del Sol - Trends in immunology, 2022 - cell.com
The molecular underpinnings of the uncontrolled release of proinflammatory cytokines and
chemokines ('cytokine storm'), which can cause organ damage and even mortality, are not …

Influenza virus causes lung immunopathology through down-regulating PPARγ activity in macrophages

H Zhang, T Alford, S Liu, D Zhou, J Wang - Frontiers in Immunology, 2022 - frontiersin.org
Fatal influenza (flu) virus infection often activates excessive inflammatory signals, leading to
multi-organ failure and death, also referred to as cytokine storm. PPARγ (Peroxisome …