In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …

Subarachnoid haemorrhage (SAH) is a common cerebrovascular disease with high
disability and mortality rates worldwide. The pathophysiological mechanisms involved in an …

Background & Aims Oxidative stress-mediated ferroptosis and macrophage-related
inflammation play an important role in various liver diseases. Here, we explored if and how …

Pathogenesis exploration and timely intervention of lung injury is quite necessary as it has
harmed human health worldwide for years. Ficolin B (Fcn B) is a recognition molecule that …

The nucleotide-binding domain leucine-rich repeat-receptor, pyrin domain-containing-3
(NLRP3) inflammasome contributes to the inflammatory response by activating caspase-1 …

Ischemic stroke, a primary cause of disability and the second leading cause of mortality, has
emerged as an urgent public health issue. Growing evidence suggests that the Cyclic GMP …

Traumatic brain injury (TBI) survivors frequently suffer from chronically progressive
complications, including significantly increased risk of developing aging-related …

Pain is a common clinical condition. However, the mechanisms underlying pain are not yet
fully understood. It is known that the neuroimmune system plays a critical role in the …

Background Ischaemia-evoked neuroinflammation is a critical pathogenic event following
ischaemic stroke. Gasdermin D (GSDMD)-associated pyroptosis represents a type of …

Emerging evidence shows that targeting ferroptosis may be a potential therapeutic strategy
for treating traumatic brain injury (TBI). Hydrogen sulfide (H2S) has been proven to play a …