The role of natural killer cells in autoimmune diseases

UC Kucuksezer, E Aktas Cetin, F Esen… - Frontiers in …, 2021 - frontiersin.org
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

[PDF][PDF] One year in review 2020: Behçet's syndrome

G Hatemi, E Seyahi, I Fresko, R Talarico… - Clin Exp …, 2020 - clinexprheumatol.org
Behçet's syndrome is a variable vessel vasculitis with multi-system involvement that shows
important heterogeneity among patients regarding demographic features, organ …

Pathogenesis of non-infectious uveitis elucidated by recent genetic findings

M Takeuchi, N Mizuki, S Ohno - Frontiers in immunology, 2021 - frontiersin.org
Uveitis is a generic term for inflammation of the uvea, which includes the iris, ciliary body,
and choroid. Prevalence of underlying non-infectious uveitis varies by race and region and …

Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health

NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

Behçet disease (BD) and BD‐like clinical phenotypes: NF‐κB pathway in mucosal ulcerating diseases

SF Perazzio, EJ Allenspach, KK Eklund… - Scandinavian …, 2020 - Wiley Online Library
Behçet's disease (BD) is a heterogeneous multi‐organ disorder in search of a unified
pathophysiological theory and classification. The disease frequently has overlapping …

ERAP1, ERAP2, and two copies of HLA-aw19 alleles increase the risk for birdshot chorioretinopathy in HLA-A29 carriers

S Gelfman, D Monnet, AJ Ligocki… - … & Visual Science, 2021 - iovs.arvojournals.org
Purpose: Birdshot chorioretinopathy (BSCR) is strongly associated with HLA-A29. This study
was designed to elucidate the genetic modifiers of BSCR in HLA-A29 carriers. Methods: We …

Behçet's Disease: A Comprehensive Review on the Role of HLA-B*51, Antigen Presentation, and Inflammatory Cascade

S Khoshbakht, D Başkurt, A Vural, S Vural - International Journal of …, 2023 - mdpi.com
Behçet's disease (BD) is a complex, recurring inflammatory disorder with autoinflammatory
and autoimmune components. This comprehensive review aims to explore BD's …

Association of functional polymorphisms of KIR3DL1/DS1 with Behcet's disease

Á Castaño-Núñez, MA Montes-Cano… - Frontiers in …, 2019 - frontiersin.org
Behçet's disease (BD) is an immune-mediated vasculitis related to imbalances between the
innate and adaptive immune response. Infectious agents or environmental factors may …

KIR variation in Iranians combines high haplotype and allotype diversity with an abundance of functional inhibitory receptors

C Alicata, E Ashouri, N Nemat-Gorgani… - Frontiers in …, 2020 - frontiersin.org
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells.
They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) …

Killer cell immunoglobulin-like receptor variants are associated with protection from symptoms associated with more severe course in Parkinson disease

KM Anderson, DG Augusto, R Dandekar… - The Journal of …, 2020 - journals.aai.org
Immune dysfunction plays a role in the development of Parkinson disease (PD). NK cells
regulate immune functions and are modulated by killer cell immunoglobulin-like receptors …