Prevalence of asthma in older adults is growing along with increasing global life expectancy.
Due to poor clinical consequences such as high mortality, advancement in understanding …

Organismal ageing is associated with many physiological changes, including differences in
the immune system of most animals. These differences are often considered to be a key …

The magnitude and quality of the germinal center (GC) response decline with age, resulting
in poor vaccine-induced immunity in older individuals. A functional GC requires the co …

Background The spread of SARS-CoV-2 has caused a worldwide pandemic that has
affected almost every aspect of human life. The development of an effective COVID-19 …

Memory B cells (MBCs) can provide a recall response able to supplement waning
antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses …

Increasing age is the strongest predictor of risk of COVID-19 severity and mortality.
Immunometabolic switch from glycolysis to ketolysis protects against inflammatory damage …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain,
germinal center (GC) reactions. However, the precise roles of these cells in the complex GC …

Renal ischemia-reperfusion injury (IRI) is a non-negligible clinical challenge for clinicians in
surgeries such as renal transplantation. Functional loss of renal tubular epithelial cell (TEC) …

Adult females of reproductive age develop greater antibody responses to inactivated
influenza vaccines (IIV) than males. How sex, age, and sex steroid concentrations impact B …