Long COVID (LC) encompasses a constellation of long-term symptoms experienced by at
least 10% of people after the initial SARS-CoV-2 infection, and so far it has affected about 65 …

It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …

Mortality in acute infections is mostly associated with sepsis, defined as 'life-threatening
organ dysfunction caused by a dysregulated host response to infection'. It remains …

Background: Risk of severe COVID-19 increases with age, is greater in males, and is
associated with lymphopenia, but not with higher burden of SARS-CoV-2. It is unknown …

Ensuring high vaccination and even booster vaccination coverage is critical in preventing
severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines …

Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability
state with high risk of life-threatening thromboembolic complications. However, the …

A gradual decay in humoral and cellular immune responses over time upon SAR1S-CoV-2
vaccination may cause a lack of protective immunity. We conducted a longitudinal analysis …

Beyond diseases and syndromes, there are some other conditions, such as fatigue, which
are frequently reported by older people and represent unmet clinical needs. In particular …

Background In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection
is characterized by major immune dysfunctions. The capacity of these severe patients to …

Despite timely immunization programs, and efficacious vaccines conveying protection
against SARS-CoV-2 infection, breakthrough infections in vaccinated individuals have been …