Human longevity is a complex phenotype with a significant familial component, yet little is
known about its genetic antecedents. Increasing evidence from animal models suggests that …

Longevity and healthy aging are among the most complex phenotypes studied to date. The
heritability of age at death in adulthood is approximately 25%. Studies of exceptionally long …

Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …

Old-age survival has increased substantially since 1950. Death rates decelerate with age for
insects, worms, and yeast, as well as humans. This evidence of extended postreproductive …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …

Background. The genetic contribution to longevity in humans has been estimated to range
from 15% to 25%. Only two genes, APOE and FOXO3, have shown association with …

The human forkhead box O3A gene (FOXO3A) encodes an evolutionarily conserved key
regulator of the insulin–IGF1 signaling pathway that is known to influence metabolism and …

The Social Science Encyclopedia, first published in 1985 to acclaim from social scientists,
librarians and students, was thoroughly revised in 1996, when reviewers began to describe …