Context.—Physical activity and fitness are believed to reduce premature mortality, but
whether genetic factors modify this effect is not known. Objective.—To investigate leisure …

Sickle cell anemia is associated with unusual clinical heterogeneity for a Mendelian
disorder. Fetal hemoglobin concentration and coincident α thalassemia, both which directly …

Healthy aging and longevity in humans are modulated by a lucky combination of genetic
and non-genetic factors. Family studies demonstrated that about 25% of the variation in …

Like most complex phenotypes, exceptional longevity is thought to reflect a combined
influence of environmental (eg, lifestyle choices, where we live) and genetic factors. To …

Great apes, our closest living relatives, live longer and mature later than most other
mammals and modern humans are even later‐maturing and potentially longer‐lived …

ContextExcessive calorie intake and subsequent obesity increases the risk of developing
chronic disease and decreases life expectancy. In rodent models, calorie restriction with …

This is a book about adult development. Such a simple statement, but it implies a lot. This is
not just a catalogue of facts about adults, or a personality text that deals with the origins of …

The genetic contribution to the variation in human lifespan is∼ 25%. Despite the large
number of identified disease-susceptibility loci, it is not known which loci influence …

To better characterize aging in mice, the Jackson Aging Center carried out a lifespan study
of 31 genetically‐diverse inbred mouse strains housed in a specific pathogen‐free facility …

For human complex traits, non-additive genetic variation has been invoked to explain"
missing heritability," but its discovery is often neglected in genome-wide association studies …