Twin studies show that genetic differences account for about a quarter of the variance in
adult human lifespan. Common polymorphisms that have a modest effect on lifespan have …

In her surprising, entertaining and persuasive new book, award-winning author and
psychologist Susan Pinker shows how face-to-face contact is crucial for learning, happiness …

Background Human ageing is a complex, multifactorial process and early developmental
factors affect health outcomes in old age. Methods Metabolomic profiling on fasting blood …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents' survival, we …

Objectives To determine the contribution of progress in averting premature deaths to the
increase in life expectancy and the decline in lifespan variation. Design International …

There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

Here we summarize the latest data on genetic and epigenetic contributions to human aging
and longevity. Whereas environmental and lifestyle factors are important at younger ages …

We conducted a sib pair study in very old subjects for the purpose of mapping longevity loci.
In the present analysis, we explore whether our recruitment strategy has resulted in a …

The role of genetics in determining life-span is complex and paradoxical. Although the
heritability of life-span is relatively minor, some genetic variants significantly modify …

The New England Centenarian Study (NECS) was founded in 1994 as a longitudinal study
of centenarians to determine if centenarians could be a model of healthy human aging. Over …