Longevity as a complex life-history trait shares an ontogenetic relationship with other
quantitative traits and varies among individuals, families and populations. Heritability …

Compression of mortality is measured here in four ways:(1) by standard deviation of the age
at death above the mode;(2) by standard deviation of the age at death in the highest …

The membrane pacemaker theory of aging is an extension of the oxidative stress theory of
aging. It emphasises variation in the fatty acid composition of membranes as an important …

This report reviews decade two of the lifetime diet restriction study of the dog. Labrador
retrievers (n 48) were paired at age 6 weeks by sex and weight within each of seven litters …

This review focuses on the determinants of longevity in the industrialized world, with
emphasis on results from recently established data bases. Strong evidence is now available …

[Frontiers in Bioscience E4,768-778, January 1, 2012] 768 Role of sirtuins, calorie
restriction and physical activity in aging G Page 1 [Frontiers in Bioscience E4,768-778 …

The idea that human longevity is influenced by genetic factors has recently received strong
support from work on other species. On the basis of partial population studies and selected …

Variation in human lifespan is 20 to 30% heritable in twins but few genetic variants have
been identified. We undertook a Genome Wide Association Study (GWAS) using age at …

Three dimensions of the survival curve have been developed:(1)“horizontalization,” which
corresponds to how long a cohort and how many survivors can live before aging-related …

Survival to extreme ages clusters within families. However, identifying genetic loci conferring
longevity and low morbidity in such longevous families is challenging. There is debate …