The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

In contrast to early lung development, a process exemplified by the branching of the
developing airways, the later development of the immature lung remains very poorly …

Hepatic ischemia-reperfusion injury (IRI) is a common complication occurs during hepatic
resection and transplantation. However, the mechanisms underlying hepatic IRI have not …

Developing, regenerating, and repairing a lung all require interstitial resident fibroblasts
(iReFs) to direct the behavior of the epithelial stem cell niche. During lung development …

Although the importance of platelet-derived growth factor receptor (PDGFR)-α signaling
during normal alveogenesis is known, it is unclear whether this signaling pathway can …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
accumulation of extracellular matrix (ECM) and impaired gas exchange. The pathobiological …

Idiopathic pulmonary fibrosis (IPF) is characterized by an accumulation of extracellular
matrix proteins and fibroblasts in the distal airways. Key developmental lung signaling …

Background Ethiopian sheep populations such as Arsi-Bale, Horro and Adilo (long fat-tailed,
LFT) inhabit mid to high-altitude areas; and Menz sheep (MZ, short fat-tailed) are adapted to …

High-throughput genomic technologies have identified biomarkers and potential therapeutic
targets for ovarian cancer. Comprehensive functional validation studies of the biological and …

During lung development, the mesenchyme and epithelium are dependent on each other for
instructive morphogenic cues that direct proliferation, cellular differentiation and …