Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis
Background Major depression is a disabling psychiatric illness with complex origins. Life
stress (childhood adversity and recent stressful events) is a robust risk factor for depression …
stress (childhood adversity and recent stressful events) is a robust risk factor for depression …
The motivated gatekeeper of our minds: New directions in need for closure theory and research
For over three decades, the need for closure (NFC) construct has played a pivotal role in
research programs addressing the motivational underpinnings of knowledge formation …
research programs addressing the motivational underpinnings of knowledge formation …
Developmental timing of polyvictimization: Continuity, change, and association with adverse outcomes in adolescence
Children who experience polyvictimization (ie, exposure to multiple and varied traumatic
stressors) are at heightened risk for psychopathology. While polyvictims generally have …
stressors) are at heightened risk for psychopathology. While polyvictims generally have …
Polygenic interactions with environmental adversity in the aetiology of major depressive disorder
BackgroundMajor depressive disorder (MDD) is a common and disabling condition with well-
established heritability and environmental risk factors. Gene–environment interaction …
established heritability and environmental risk factors. Gene–environment interaction …
Effect of polygenic risk scores on depression in childhood trauma
WJ Peyrot, Y Milaneschi, A Abdellaoui… - The British Journal of …, 2014 - cambridge.org
BackgroundResearch on gene× environment interaction in major depressive disorder
(MDD) has thus far primarily focused on candidate genes, although genetic effects are …
(MDD) has thus far primarily focused on candidate genes, although genetic effects are …
The reciprocal interaction between serotonin and social behaviour
Serotonin (5-HT) is an ancient molecule directing behavioural responses to environmental
stimuli. The social environment is the most powerful environmental factor. It is well …
stimuli. The social environment is the most powerful environmental factor. It is well …
An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings
CF Sharpley, SKA Palanisamy, NS Glyde… - Behavioural brain …, 2014 - Elsevier
In the three years since the most recent meta-analysis of the association between the
serotonin transported promoter polymorphism (5-HTTLPR), stress and the development of …
serotonin transported promoter polymorphism (5-HTTLPR), stress and the development of …
Gene× environment interactions: from molecular mechanisms to behavior
T Halldorsdottir, EB Binder - Annual Review of Psychology, 2017 - annualreviews.org
Gene-by-environment interactions (G× Es) can provide important biological insights into
psychiatric disorders and may consequently have direct clinical implications. In this review …
psychiatric disorders and may consequently have direct clinical implications. In this review …
In my end is my beginning: Developmental trajectories of adverse childhood experiences to late-life suicide
Objectives: Converging evidence suggests that the sequelae of adverse childhood
experiences (ACEs) including childhood abuse (eg, sexual, physical, emotional/verbal …
experiences (ACEs) including childhood abuse (eg, sexual, physical, emotional/verbal …
DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy …
Serotonin plays an important role in the etiology of depression. Serotonin is also crucial for
brain development. For instance, animal studies have demonstrated that early disruptions in …
brain development. For instance, animal studies have demonstrated that early disruptions in …